Biocompability evaluation of micro textures coated with zinc oxide on Ti-6Al-4V treated by nanosecond laser

Zhao, Zihe; Wan, Yi; Yu, Mingzhi; Wang, Hongwei; Cai, Yukui; Liu, Chao; Zhang, Dong

doi:10.1016/j.surfcoat.2021.127453

Cited by 19 publications

(8 citation statements)

References 44 publications

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“…On the one hand, Si, Zn, and Sr released from Zn/Sr-CS/CPCs could promote the adhesion of mBMSCs. More than one study documented that Si could create a beneficial ion microenvironment to the initial spread. , Zhao’s research reported that MC3T3s on Ti-6Al-4V-containing ZnO stretched out more filopodia. Mavropoulos et al discovered that the introduced Zn in hydroxyapatite surface facilitated RGD peptide adsorption, promoting the adhesion and spreading of MC3T3.…”

Section: Resultsmentioning

confidence: 99%

Effects of Zinc and Strontium Doping on In Vitro Osteogenesis and Angiogenesis of Calcium Silicate/Calcium Phosphate Cement

Yuan,

Wu,

et al. 2023

ACS Biomater. Sci. Eng.

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Based on multiple biological functions (mainly osteogenesis and angiogenesis) of bioactive ions, Zn/Sr-doped calcium silicate/calcium phosphate cements (Zn/Sr-CS/CPCs, including 10Zn-CS/CPC, 20Sr-CS/CPC, and 10Zn/20Sr-CS/CPC) were prepared by the addition of Zn and Sr dual active ions into CS/CPC to further accelerate its bone regeneration in this study. The physicochemical and biological properties of the Zn/Sr-CS/CPCs were systematically investigated. The results showed that the setting time was slightly prolonged, the compressive strength and porosity did not change much, and all groups maintained good injectability after the doping of Zn and Sr. Besides, the doping of Zn and Sr had little effect on the phase and microstructure of hydrated products of CS/CPC. The degradation rate of Zn/Sr-CS/CPCs decreased after doping with Zn and Sr. In mouse bone marrow mesenchymal stem cells (mBMSC) experiments, all Zn/Sr-CS/CPCs stimulated the viability, adhesion, proliferation, and alkaline phosphatase (ALP) activity together with osteogenesis-related genes (ALP, Runx2, Col-I, OCN, and OPN). The further addition of Zn and Sr played better and synergistic roles in in vitro osteogenesis. Thereinto, 10Zn/20Sr-CS/CPC manifested the optimum in vitro osteogenic performance. As for human umbilical vein endothelial cell (HUVEC) experiments, the incorporation of CS doped with Zn and Sr into CPC possessed good vascularization properties of proliferation, NO secretion, tube formation, and the expression of angiogenesis-related genes (VEGF, bFGF, and eNOS). In conclusion, the doping of Zn and Sr into CS/CPC could exhibit excellent osteogenesis and good angiogenesis potentials and 10Zn/20Sr-CS/CPC could be considered as a promising candidate in bone repair.

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Section: Resultsmentioning

confidence: 99%

Effects of Zinc and Strontium Doping on In Vitro Osteogenesis and Angiogenesis of Calcium Silicate/Calcium Phosphate Cement

Yuan,

Wu,

et al. 2023

ACS Biomater. Sci. Eng.

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“…Comparatively, laser ablation in a liquid environment is a potential alternative to surface modification of Ti substrates as it has excellent characteristics of eliminating sharp surface features and narrowing down the size distribution of nanoparticles [ 68 ]. Zhao et al successfully developed ZnO-coated microgrooves on Ti-6Al-4 V implants using a two-step nanosecond laser processing technique, which achieved a substrate surface with target morphology as well as rapid fixation of chemical composition [ 69 ]. However, this technique should be avoided in conjunction with the organic component of the biomodified Ti surface, as the high local temperature generated by the laser could be a serious cause of loss of biological activity.…”

Section: Fabrication Of Nano-zno Modified Ti Materials and Their Biosafe Propertiesmentioning

confidence: 99%

NanoZnO-modified titanium implants for enhanced anti-bacterial activity, osteogenesis and corrosion resistance

Wang

et al. 2021

J Nanobiotechnol

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Titanium (Ti) implants are widely used in dentistry and orthopedics owing to their excellent corrosion resistance, biocompatibility, and mechanical properties, which have gained increasing attention from the viewpoints of fundamental research and practical applications. Also, numerous studies have been carried out to fine-tune the micro/nanostructures of Ti and/or incorporate chemical elements to improve overall implant performance. Zinc oxide nanoparticles (nano-ZnO) are well-known for their good antibacterial properties and low cytotoxicity along with their ability to synergize with a variety of substances, which have received increasingly widespread attention as biomodification materials for implants. In this review, we summarize recent research progress on nano-ZnO modified Ti-implants. Their preparation methods of nano-ZnO modified Ti-implants are introduced, followed by a further presentation of the antibacterial, osteogenic, and anti-corrosion properties of these implants. Finally, challenges and future opportunities for nano-ZnO modified Ti-implants are proposed. Graphical Abstract

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“…Femtosecond laser surface modification combined with the fabrication of silver nanostructures was demonstrated by MacKenzie et al [57]; however, the two processes were carried out separately. The possibility of obtaining surface structuring and coating by means of laser treatment was demonstrated by Zhao et al [58]; this was made using several consecutive steps to achieve such result.…”

Section: Introductionmentioning

confidence: 99%

Single-Step Process for Titanium Surface Micro- and Nano-Structuring and In Situ Silver Nanoparticles Formation by Ultra-Short Laser Patterning

et al. 2022

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Ultra-short laser (USL)-induced surface structuring combined with nanoparticles synthesis by multiphoton photoreduction represents a novel single-step approach for commercially pure titanium (cp-Ti) surface enhancement. Such a combination leads to the formation of distinct topographical features covered by nanoparticles. The USL processing of cp-Ti in an aqueous solution of silver nitrate (AgNO3) induces the formation of micron-sized spikes surmounted by silver nanoparticles (AgNPs). The proposed approach combines the structuring and oxidation of the Ti surface and the synthesis of AgNPs in a one-step process, without the use of additional chemicals or a complex apparatus. Such a process is easy to implement, versatile and sustainable compared to alternative methodologies capable of obtaining comparable results. Antimicrobial surfaces on medical devices (e.g., surgical tools or implants), for which titanium is widely used, can be realized due to the simultaneous presence of AgNPs and micro/nano-structured surface topography. The processed surfaces were examined by means of a scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDX), atomic force microscopy (AFM) and Raman spectroscopy. The surface morphology and the oxidation, quality and quantity of AgNPs were analyzed in relation to process parameters (laser scanning speed and AgNO3 concentration), as well as the effect of AgNPs on the Raman signal of Titanium oxide.

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Biocompability evaluation of micro textures coated with zinc oxide on Ti-6Al-4V treated by nanosecond laser

Cited by 19 publications

References 44 publications

Effects of Zinc and Strontium Doping on In Vitro Osteogenesis and Angiogenesis of Calcium Silicate/Calcium Phosphate Cement

Effects of Zinc and Strontium Doping on In Vitro Osteogenesis and Angiogenesis of Calcium Silicate/Calcium Phosphate Cement

NanoZnO-modified titanium implants for enhanced anti-bacterial activity, osteogenesis and corrosion resistance

Single-Step Process for Titanium Surface Micro- and Nano-Structuring and In Situ Silver Nanoparticles Formation by Ultra-Short Laser Patterning

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