Biocide glass based on Nb2O5-SiO-CaO-Na2O system

Abstract

In this work, glasses based on SiO-CaO-Na 2 O system containing different Nb 2 O 5 contents were developed. Glasses were melted at 1500°C and quenched in a metallic mould. Citotoxicity tests were performed using neutral red uptake methodology and indicated normal cell growth, which enables the use as biomaterial. Biocide activity was evaluated through glass incubation in bacterial suspension (Escherichia coli) at 37°C under shaking. The composition with higher content of SiO 2 and lower content of Nb 2 O 5 presented higher biocide activity and the coefficient of thermal expansion indicate thermal compatibility with stainless steel 316 L and titanium alloys.

45S5 Bioglass-Derived Glass-Ceramic Scaffolds Containing Niobium Obtained by Gelcasting Method

“…In the literature, some reports about production of bioactive glass and glass-ceramic containing niobium have been found [8][9][10][11] . For example, Souza et al 11 shows in vitro and in vivo studies of a novel melt-derived Nb substituted 45S5 bioglass that exhibited similar release profile for Si, Na and Ca species compared to BG45S5, in addition to the release of niobium species by the compositions of Nbcontaining glass.…”