Biocidal properties of Chitosan-encapsulated ternary titanium dioxide-nickel oxide-copper oxide hybrid nanomaterials were prepared via a facile one-pot precipitation process

Abstract

Chitosan-encapsulated ternary titanium dioxide-nickel oxide-copper oxide (CTNC) hybrid nanomaterials (HNM) were synthesis via a facile one-pot precipitation method. The synthesized Chitosan-titanium dioxide-nickel oxide-copper oxide was characterized by XRD, UV, FTIR, DLS, FESEM, EDAX, and PL tested against G- (gram-negative) bacterial strain such as K. pneumonia, S. dysenteriae, E. coli, P. Vulgaris, P. aeruginosa, and V. cholerae, employed by the well method. The CTNC hybrid nanomaterials exhibit a more substantial antibacterial effect against gram-negative bacteria. The MDA-MB-231 cell-line, with an IC50 concentration value of 9.8 g/mL was chosen to test CTNC hybrid nanomaterials' anticancer properties against human breast cancer cell lines. The toxicity studies of fibroblast L929 cells showed that the CTNC hybrid nanomaterials were less harmful to the healthy cells. As a result, the CTNC hybrid nanomaterials can be used for biomedical and industrial applications to improve human health conditions.