Biocidal and catalytic efficiency of ruthenium(III) complexes with tridentate Schiff base ligands

Arunachalam, S.; Priya, N. Padma; Boopathi, K.; Jayabalakrishnan, Chinnasamy; Chinnusamy, V.

doi:10.1002/aoc.1647

Cited by 15 publications

(10 citation statements)

References 32 publications

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“…Firstly, FTIR experiments were performed by ATR from range 4000 cm À 1 to 600 cm À 1 using solid state L and L-Cu 2 + to Figure 8(a) showed the characteristic amide carbonyl stretching at ∼ 1643 cm À 1 and the isoniazid NH stretching in the range ∼ 3054 cm À 1 . The absence of both peaks in the Cu + 2 -L complex (Figure 8(b)) formation was validated for deprotonation of NH protons and involvement of carbonyl group and hydrazinyl group in complex formation with copper ions 54 .…”

Section: Binding Mode Of L Towards Coppermentioning

confidence: 75%

“…The UV-Visible absorption spectra of sensor L, illustrated two major absorption peaks at 263 nm and 330 nm due to π-π* and n-π* transitions, respectively, in the Schiff base moiety. [54] Upon addition of various metal ions to the sensor L, only Cu + 2 ions showed noticeable appearance of new band towards higher wavelength at ∼ 433 nm, whereas there was no change in spectra on addition of other metal ions. This spectral change could be attributed to the intramolecular charge transfer (ICT) process that takes place during the complexation between Cu + 2 ion and sensor (L).…”

Section: Colorimetric and Spectroscopic Sensing Of Cu 2 +mentioning

confidence: 91%

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Pyrrole‐Based Schiff‐Base Sensor for Copper Ions

Sidana

Kaur

et al. 2020

ChemistrySelect

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A new, simple, and reversible Schiff base, (E)‐N′‐((1H‐pyrrol‐2‐yl) methylene) isonicotinohydrazide (L), has been designed, synthesized, and characterized for its optical and elemental properties. The synthesized sensor, L is then successfully investigated for selective and sensitive detection of Cu+2 ions by the colorimetric and spectroscopic method in an aqueous organic solvent. The sensor L showed high selectivity toward Cu+2 ions over other possible interfering ions (Na+, K+, Ca+2, Mg+2,Co+2, Ni+2, Zn+2, Cd+2, Pb+2, Cr+3, Ag+, Al+3 and Mn+2) and in a wide pH range. The detection limit reaches up to 17.6 μM, which is lower than the WHO recommended guidelines for drinking water, while the limit of quantification was found to be 58 μM. The binding mode of complexation between Cu+2 and L was found to be 1 : 1 using Job's plot. For practical usage, the designed sensor (L) is transferred onto paper strips and demonstrated for real sample analysis through naked eye color change.

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Section: Binding Mode Of L Towards Coppermentioning

confidence: 75%

Section: Colorimetric and Spectroscopic Sensing Of Cu 2 +mentioning

confidence: 91%

Pyrrole‐Based Schiff‐Base Sensor for Copper Ions

Sidana

Kaur

et al. 2020

ChemistrySelect

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“…[ 104 ] These complexes also block the protein synthesis required for the growth of the organism by disturbing the respiration process of the cell. [ 105 ] The variation in the activity of the ligand and metal complexes depends on the permeability of the cell membrane or differences ribosomes of microbial cells. [ 105 ] On the other hand, the donor atoms of the ligand may inhibit the enzyme activity which require these groups for their activity appear to be especially more susceptible to deactivation by the metal ions upon chelation.…”

Section: Biological Applicationsmentioning

confidence: 99%

Synthesis, characterization, DNA binding/cleavage, cytotoxic, apoptotic, and antibacterial activities of V(IV), Mo(VI), and Ru(II) complexes containing a bioactive ONS‐donor chelating agent

El‐Afify

Elsayed

Shalaby

et al. 2020

Applied Organom Chemis

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New V(IV), Mo(VI), and Ru(II) complexes containing the ligand 2,4‐dihydroxyacetophenone‐S‐methyl dithiocarbazate (H2dhasm); [VO(dhasm)(bpy)] (1) (bpy = 2,2′‐bipyridine), [VO(dhasm)(phen)] (2) (phen = 1,10‐phenanthroline), [MoO2(dhasm)(imz)] (3) (imz = imidazole), [MoO2(dhasm)(DMSO)] (4) (DMSO = dimethylsulfoxide), and [Ru(CO)(PPh3)2(dhasm)] (5) have been synthesized. The ligand and its complexes were structurally characterized by elemental analyses, IR, 1H NMR, EPR, ultraviolet (UV)–visible spectroscopies, magnetic susceptibility, and cyclic voltammetry measurements. Single crystal X‐ray crystallography was used to establish the structure detail of (3) and (4) complexes confirming that the ligand coordinate to the metal ion in a bi‐negative tridentate fashion (dhasm2−, ONS‐donor) in a distorted octahedral geometry. The interaction with calf thymus DNA (CT DNA) of all compounds was studied by UV–visible and fluorescence spectroscopies. Both studies confirmed that these compounds bind to CT DNA through intercalation mode. The DNA cleavage activity of the complexes was also studied on plasmid DNA using gel agarose electrophoresis, and the results revealed that only complexes (2) and (5) have superior cleavage activity in the presence of H2O2. The cytotoxic activity (in vitro) of the complexes on three human cancer cell lines; human liver hepatocellular carcinoma (HepG2), breast adenocarcinoma (MCF7), and epitheliod carcinoma (Hela); and a normal human lung fibroblast (WI‐38) was studied using MTT assay. The complexes exhibited a strong cytotoxicity effect compared with their parent ligand. The ruthenium(II) complex (5) showed the most potent growth inhibition of cancer cells. Also, the mechanism of the apoptotic death in HepG2 cells was studied by observing an increased gene expression of caspase‐3, BAX, P53 and decreased Bcl2 gene expression. The complexes were also screened for their antibacterial activity against gram‐positive and gram‐negative bacteria and showed significant activity against both microorganisms.

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“…All the orchestrated Co and Cu complexes were found to catalyze the oxidation of alcohols to aldehydes/ketones, yet the yields and the turnover were found to fluctuate with various impetuses. The generally higher item yield got for the oxidation of benzyl liquor than for cyclohexanol was because of the way that the α-CH moiety of benzyl alcohol is more acidic than that of cyclohexanol [15]. The moderately higher item yield got for the oxidation of cinamyl alcohol than benzyl alcohol is because of the nearness of unsaturated aliphatic gathering in the cinnamyl alcohol [16].…”

Section: F Catalyic Activities Catalytic Oxidationmentioning

confidence: 98%

“…The catalytic oxidation and the C-C coupling reactions were done by using the reported literatures [14], [15]…”

Section: Catalytic Acivitymentioning

confidence: 99%

Transition Metal Schiff Base Complexes Synthesis, Spectral Examination and used as a Catalyst in the Oxidation of Alcohols and C-C Coupling Reactions

2019

IJITEE

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In this correspondence, it reveals the formation of Co (II) and Cu (II) complexes consists of a Schiff base ligand having the four donar destinations 2NO. Co(II) and Cu(II) complexes were made ready by the response of 1:1 proportion of the MCl2 .6H2O (M = Co/Cu) with a Schiff base ligand prepared by the response of 2-hydroxynaphthaldehyde with orthophenylene diamine in ethanolic medium having the stoichimetric proportion of 2:1. The purged and arranged complexes were analytically explored. Catalytic efficacy was assessed for oxidation of alcohols and C-C coupling responses.

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Biocidal and catalytic efficiency of ruthenium(III) complexes with tridentate Schiff base ligands

Cited by 15 publications

References 32 publications

Pyrrole‐Based Schiff‐Base Sensor for Copper Ions

Pyrrole‐Based Schiff‐Base Sensor for Copper Ions

Synthesis, characterization, DNA binding/cleavage, cytotoxic, apoptotic, and antibacterial activities of V(IV), Mo(VI), and Ru(II) complexes containing a bioactive ONS‐donor chelating agent

Transition Metal Schiff Base Complexes Synthesis, Spectral Examination and used as a Catalyst in the Oxidation of Alcohols and C-C Coupling Reactions

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