Biocidal activity of cellulose materials for medical implants

Onofrei, Mihaela Dorina; Dobos, Adina Maria; Dunca, Simona; Ioanid, Emil Ghiocel; Ioan, Silvia

doi:10.1002/app.41932

Cited by 12 publications

(6 citation statements)

References 51 publications

(66 reference statements)

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“…In Table 2, the known surface free energy parameters for the three test liquids, red blood cell membrane, and platelets [87,88,89,90,91] are listed.…”

Section: Methodsmentioning

confidence: 99%

Biocompatible Materials Based on Plasticized Poly(lactic acid), Chitosan and Rosemary Ethanolic Extract I. Effect of Chitosan on the Properties of Plasticized Poly(lactic acid) Materials

et al. 2019

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The purpose of the present study is to develop new multifunctional environmentally friendly materials having applications both in medical and food packaging fields. New poly(lactic acid) (PLA)-based multifunctional materials containing additives derived from natural resources like chitosan (CS) and rosemary extract (R) were obtained by melt mixing. Each of the selected components has its own specific properties such as: PLA is a biodegradable thermoplastic aliphatic polyester derived from renewable biomass, heat-resistant, with mechanical properties close to those of polystyrene and polyethylene terephthalate, and CS offers good antimicrobial activity and biological functions, while R significantly improves antioxidative action necessary in all applications. A synergy of their combination, an optimum choice of their ratio, and processing parameters led to high performance antimicrobial/antioxidant/biocompatible/environmentally degradable materials. The polyethylene glycol (PEG)-plasticized PLA/chitosan/powdered rosemary extract biocomposites of various compositions were characterized in respect to their mechanical and rheological properties, structure by spectroscopy, antioxidant and antimicrobial activities, and in vitro and in vivo biocompatibility. Scanning electron microscopy images evidence the morphology features added by rosemary powder presence in polymeric materials. Incorporation of additives improved elongation at break, antibacterial and antioxidant activity and also biocompatibility. Migration of bioactive components into D1 simulant is slower for PEG-plasticized PLA containing 6 wt % chitosan and 0.5 wt % rosemary extract (PLA/PEG/6CS/0.5 R) biocomposite and it occurred by a diffusion-controlled mechanism. The biocomposites show high hydrophilicity and good in vitro and in vivo biocompatibility. No hematological, biochemical and immunological modifications are induced by subcutaneous implantation of biocomposites. All characteristics of the PEG-plasticized PLA-based biocomposites recommend them as valuable materials for biomedical implants, and as well as for the design of innovative drug delivery systems. Also, the developed biocomposites could be a potential nature-derived active packaging with controlled release of antimicrobial/antioxidant compounds.

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“…In Table 2, the known surface free energy parameters for the three test liquids, red blood cell membrane, and platelets [87,88,89,90,91] are listed.…”

Section: Methodsmentioning

confidence: 99%

Biocompatible Materials Based on Plasticized Poly(lactic acid), Chitosan and Rosemary Ethanolic Extract I. Effect of Chitosan on the Properties of Plasticized Poly(lactic acid) Materials

et al. 2019

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“…To determine the total surface free energy of the solid material (

) a system based on Equation (4) must be used. To solve the resulting systems of equations it is necessary to use at least three test liquids with known

, and

, see Table 2 [ 45 , 46 , 47 , 48 ].…”

Section: Methodsmentioning

confidence: 99%

Evaluation of the Rosemary Extract Effect on the Properties of Polylactic Acid-Based Materials

Darie-Niță¹,

Vasile²,

Stoleru³

et al. 2018

Materials

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New multifunctional materials containing additives derived from natural resources as powdered rosemary ethanolic extract were obtained by melt mixing and processed in good conditions without degradation and loss of additives. Incorporation of powdered rosemary ethanolic extract (R) into poly(lactic acid) (PLA) improved elongation at break, rheological properties, antibacterial and antioxidant activities, in addition to the biocompatibility. The good accordance between results of the chemiluminescence method and radical scavenging activity determination by chemical method evidenced the increased thermoxidative stability of the PLA biocomposites with respect to neat PLA, with R acting as an antioxidant. PLA/R biocomposites also showed low permeability to gases and migration rates of the bioactive compounds and could be considered as high-performance materials for food packaging. In vitro biocompatibility based on the determination of surface properties demonstrated a good hydrophilicity, better spreading and division of fibroblasts, and increased platelet cohesion. The implantation of PLA/R pellets, was proven to possess a good in vivo biocompatibility, and resulted in similar changes in blood parameters and biochemical responses with the control group, suggesting that these PLA-based materials demonstrate very desirable properties as potential biomaterials, useful in human medicine for tissue engineering, wound management, orthopedic devices, scaffolds, drug delivery systems, etc. Therefore, PLA/R-based materials show promising properties for applications both in food packaging and as bioactive biomaterials.

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“…To solve the resulting systems of equations, it is necessary to use at least three test liquids with known g lv , g LW lv , g À lv and g þ lv ( Table 2). [33][34][35][36] The subscripts 'lv' and 'sv' denote the interfacial liquid-vapor and surface-vapor tensions respectively, while the superscripts 'p' and 'd' denote the polar and disperse components respectively of total surface tension g sv . …”

Section: Contact Angle and Surface Free Energymentioning

confidence: 99%

Complex poly(lactic acid)-based biomaterial for urinary catheters: II. Biocompatibility

StoleruElena¹,

Bogdanel

Raluca³

et al. 2016

Bioinspired, Biomimetic and Nanobiomaterials

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The present paper is focused on the surface and bulk characterization of poly(lactic acid) (PLA)-based composites that contain hydrolyzed collagen as a biological polymer, silver nanoparticles and vitamin E and epoxidized soybean oil as a plasticizer. The bionanocomposites were obtained by melt processing and evaluated for structural and surface characteristics, biocompatibility, functional properties such as antimicrobial and antioxidant activity and hydrolytic degradation behavior. It has been established that the optimal composition to impart functional properties to the PLA matrix is a formulation containing 15% epoxidized soybean oil, 15% hydrolyzed collagen, 5% Pluronic, 5% vitamin E and 0·3% silver nanoparticles. This bionanocomposite inhibits the growth of both Gram-positive bacteria, Escherichia coli and Salmonella typhimurium, and Gram-negative bacteria, Listeria monocytogenes, and reaches 100% radical-scavenging activity. The PLA-based biomaterials obtained in this study are stable in biological media in the short and medium terms and therefore are recommended as multifunctional biomaterials for the manufacture of medical devices, such as urinary catheters.

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Biocidal activity of cellulose materials for medical implants

Cited by 12 publications

References 51 publications

Biocompatible Materials Based on Plasticized Poly(lactic acid), Chitosan and Rosemary Ethanolic Extract I. Effect of Chitosan on the Properties of Plasticized Poly(lactic acid) Materials

Biocompatible Materials Based on Plasticized Poly(lactic acid), Chitosan and Rosemary Ethanolic Extract I. Effect of Chitosan on the Properties of Plasticized Poly(lactic acid) Materials

Evaluation of the Rosemary Extract Effect on the Properties of Polylactic Acid-Based Materials

Complex poly(lactic acid)-based biomaterial for urinary catheters: II. Biocompatibility

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