Biochip readout system for point-of-care applications

Brandenburg, Albrecht; Curdt, Franziska; Sulz, Gerd; Ebling, F.; Nestler, J.; Wunderlich, Kai; Michel, Dirk

doi:10.1016/j.snb.2009.02.052

Cited by 15 publications

(3 citation statements)

References 14 publications

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“…Since the current POC system dissipates about tens of watts of average power, including fluidic manipulation and readout, two AA-size batteries with a capacity of 1600 mAh at a nominal voltage of 1.2V can only sustain that system for tens of minutes. While the handheld readers are typically re-usable, the microfluidic cartridge for this reader is disposable (Ahn et al, 2004;Brandenburg et al, 2009).…”

Section: Battery-powered Handheld Instrumentsmentioning

confidence: 99%

Powering point-of-care diagnostic devices

Choi

2016

Biotechnology Advances

101

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Effective and rapid point-of-care (POC) diagnostics have the capability to revolutionize public healthcare both in developed and developing countries. One of the key challenges that is critical to address in developing POC devices is to effectively and sufficiently power them. In developing countries, where the electricity grid is not well established and the use of batteries is not cost-effective, power supplies are the most problematic issue for stand-alone and self-sustained POC devices. In this review, we provide an overview of techniques for powering POC diagnostic devices for use in both developed and developing countries, as well as detailed discussions of recent advancements in POC devices. Then, we discuss next-generation POC diagnostics and their power source strategies.

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Section: Battery-powered Handheld Instrumentsmentioning

confidence: 99%

Powering point-of-care diagnostic devices

Choi

2016

Biotechnology Advances

101

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“…In a joint project of seven Fraunhofer Institutes a lab-on-chip system has been established which possesses a high degree of integration and modularity to serve the needs of the market as well as developments in biomedicine. 25 With this consortium it is possible to cover the whole value chain necessary to establish a lab-on-chip system that is ready for the market. The different sub-projects are described ranging from the microfluidic cartridge design, assay development and its transfer into the cartridge, the use of different sensor principles to the production of these cartridges to match the economies of scale.…”

Section: Introductionmentioning

confidence: 99%

Highly-integrated lab-on-chip system for point-of-care multiparameter analysis

et al. 2012

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A novel innovative approach towards a marketable lab-on-chip system for point-of-care in vitro diagnostics is reported. In a consortium of seven Fraunhofer Institutes a lab-on-chip system called "Fraunhofer ivD-platform" has been established which opens up the possibility for an on-site analysis at low costs. The system features a high degree of modularity and integration. Modularity allows the adaption of common and established assay types of various formats. Integration lets the system move from the laboratory to the point-of-need. By making use of the microarray format the lab-on-chip system also addresses new trends in biomedicine. Research topics such as personalized medicine or companion diagnostics show that multiparameter analyses are an added value for diagnostics, therapy as well as therapy control. These goals are addressed with a low-cost and self-contained cartridge, since reagents, microfluidic actuators and various sensors are integrated within the cartridge. In combination with a fully automated instrumentation (read-out and processing unit) a diagnostic assay can be performed in about 15 min. Via a user-friendly interface the read-out unit itself performs the assay protocol, data acquisition and data analysis. So far, example assays for nucleic acids (detection of different pathogens) and protein markers (such as CRP and PSA) have been established using an electrochemical read-out based on redoxcycling or an optical read-out based on total internal reflectance fluorescence (TIRF). It could be shown that the assay performance within the cartridge is similar to that found for the same assay in a microtiter plate. Furthermore, recent developments are the integration of sample preparation and polymerase chain reaction (PCR) on-chip. Hence, the instrument is capable of providing heating-and-cooling cycles necessary for DNA-amplification. In addition to scientific aspects also the production of such a lab-on-chip system was part of the development since this heavily affects the success of a later market launch. In summary, the Fraunhofer ivD-platform covers the whole value chain ranging from microfluidics, material and polymer sciences, assay and sensor development to the production and assembly design. In this consortium the gap between diagnostic needs and available technologies can be closed.

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“…Therefore, the current trend is to develop label-free methods that are able to monitor the binding reaction in real-time and provide useful information about the binding kinetics and equilibrium [6]. Label-free detection methods include surface plasmon resonance (SPR) [7,8], grating couplers [9,10], ellipsometry [11], evanescent wave devices [12,13], and reflectometry [14,15]. Most of these methods have detection limits comparable to those achieved with methods involving labeled immunoreagents.…”

Section: Introductionmentioning

confidence: 99%