Biochemometry identifies ostruthin as pluripotent antimicrobial and anthelmintic agent from masterwort

Zwirchmayr, Julia; Cruz, Cristina D.; Grienke, Ulrike; Tammela, Päivi; Rollinger, Judith M.

doi:10.1016/j.isci.2023.107523

Cited by 4 publications

(3 citation statements)

References 79 publications

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“…Simultaneously, survival assay tests for nematotoxicity, which is marked by a sharp decrease in life span and is an accepted preclinical indicator for general toxicity [29]. As a side note, C. elegans has evolved as an appropriate effective and costefficient model to also evaluate anthelmintic activity [21].…”

Section: Resultsmentioning

confidence: 99%

“…When deciphering the bioactive constituents of an extract, C. elegans assays are valuable tools in the process of bioactivity-guided fractionation [14]. The miniaturized 96-well plate format enables the bioactivity assessment of various fractions of an extract in a timeand sample-saving manner [21]. The variety of assays using both wild-type animals (N2) and mutants seems to be almost unlimited, ranging from phenotypic assessment of life span, age, and disease-specific changes to detailed experiments focusing on various transcription factors [14].…”

Section: Application Of 3rs In Caenorhabditis Elegans Research For Th...mentioning

confidence: 99%

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Application of 3Rs in Caenorhabditis elegans Research for the Identification of Health-Promoting Natural Products

Redl,

Shayegan,

Rollinger

2024

Planta Med

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The average age of the population is increasing worldwide, which has a profound impact on our society. This leads to an increasing demand for medicines and requires the development of new strategies to promote health during the additional years. In the search for resources and therapeutics for improved health during an extended life span, attention has to be paid to environmental exposure and ecosystem burdens that inevitably emerge with the extended consumption of medicines and drug development, even in the preclinical stage. The hereby introduced sustainable strategy for drug discovery is built on 3Rs, “Robustness, Reliability, and saving Resources”, inspired by both the 3Rs used in animal experiments and environmental protection, and centers on the usefulness and the variety of the small model organism Caenorhabditis elegans for detecting health-promoting natural products. A workflow encompassing a multilevel screening approach is presented to maximize the amount of information on health-promoting samples, while considering the 3Rs. A detailed, methodology- and praxis-oriented compilation and discussion of proposed C. elegans health span assays and more disease-specific assays are presented to offer guidance for scientists intending to work with C. elegans, thus facilitating the initial steps towards the integration of C. elegans assays in their laboratories.

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Section: Resultsmentioning

confidence: 99%

Section: Application Of 3rs In Caenorhabditis Elegans Research For Th...mentioning

confidence: 99%

Application of 3Rs in Caenorhabditis elegans Research for the Identification of Health-Promoting Natural Products

Redl,

Shayegan,

Rollinger

2024

Planta Med

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“…[359][360][361] With this technique, it is possible to distinguish bioactives from inactives prior to isolation, as shown by the example of masterwort. 362…”

Section: Reviewmentioning

confidence: 99%

The role of Caenorhabditis elegans in the discovery of natural products for healthy aging

et al. 2023

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Flavone and 3-hydroxyflavone supplementation in cryopreservation medium protects canine sperm against apoptosis and lipid peroxidation

Partyka,

Kostrzewa Susłow,

Dymarska

et al. 2024

Theriogenology

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Biochemometry identifies ostruthin as pluripotent antimicrobial and anthelmintic agent from masterwort

Cited by 4 publications

References 79 publications

Application of 3Rs in Caenorhabditis elegans Research for the Identification of Health-Promoting Natural Products

Application of 3Rs in Caenorhabditis elegans Research for the Identification of Health-Promoting Natural Products

The role of Caenorhabditis elegans in the discovery of natural products for healthy aging

Flavone and 3-hydroxyflavone supplementation in cryopreservation medium protects canine sperm against apoptosis and lipid peroxidation

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