Biochemical Pharmacology volume 78, issue 2, P203-210 2009 DOI: 10.1016/j.bcp.2009.03.032 View full text
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Jia-Jing Wu, Hung-Kuan Tang, Teng-Kuang Yeh, Chi-Min Chen, Hrong-Shing Shy, Yue-Ru Chu, Chia-Hui Chien, Ting-Yueh Tsai, Yu-Chen Huang, Yu-Lin Huang, Chih-Hsiang Huang, Huan-Yi Tseng, Weir-Torn Jiaang, Yu-Sheng Chao et al.

Abstract: DPP-IV (EC 3.4.14.5) is a validated drug target for human type II diabetes. DPP-IV inhibitors without DPP8/9 inhibitory activity have been sought because a possible association has been reported between a "DPP8/9 inhibitor" and severe toxicity in animals. However, at present, it is not known whether the observed toxicity is associated with DPP8/9 inhibition, or an off-target effect induced by the compound. We investigated whether the inhibition of DPP8/9 is the cause of the severe toxicity in animals using a v…

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