Biochemistry of muscle membranes in Duchenne muscular dystrophy

Rowland, Lewis P.

doi:10.1002/mus.880030103

Cited by 261 publications

(70 citation statements)

References 220 publications

(5 reference statements)

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“…DMD is a genetic disease and different cell surface membranes share many similar properties. Rowland, L.P. [51] has studied the relatively in exhaustible supply of membrane in the red blood cell and this has led to a legion of studies.…”

Section: Introductionmentioning

confidence: 99%

Role of Complements and Immunoglobulins in Duchenne Muscular Dystrophy

Kumar¹,

Mittal²,

nbsp³

et al. 2014

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Muscular dystrophies are myopathies and tend to progressive, with ongoing degeneration and regeneration of muscle fibers. Spinal muscular atrophy (SMA), amyotrophic lateral sclerosis (ALS) and polio myelitis are essentially diseases of the anterior horn cells of the spine. It has been reported in literature that humoral immunity is manifested by the antibodies production. These are special chemical substances that react against foreign body. Antibodies are serum proteins, which are immunoglobulins and possess antibody activity and are classified according to antigens and stimulate their production such as IgA, JgG, IgM, IgD and IgE. All the immunological parameters such as of C3, C4, IgG, IgM and IgA, which are measured in Duchenne muscular dystrophy go down in comparison to healthy subjects. Complement C3 and Complement C4 go down about 44.3% and 78.57% respectively from the normal values. The serum IgG, IgM and IgA levels were also go down about 65%, 84% and 99.56% respectively in comparison to healthy subjects. A trend between all the immunoglobulins has been set up and it is rAG.M > rMA.G. > rGM.A, while we have a trend in DMD cases is rMA.G. > rAG.M > rGM.A. We are in a position to say that our data have a relevance of high authenticity and reliability to accept that there is a deficit in immunity in DMD cases. The deficit in immunity may be a cause to damage muscle for abnormal functioning.

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Section: Introductionmentioning

confidence: 99%

Role of Complements and Immunoglobulins in Duchenne Muscular Dystrophy

Kumar¹,

Mittal²,

nbsp³

et al. 2014

OJAppS

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“…Phospholipids are important components of cell membranes and have been the subject of numerous biochemical studies in both muscle and erythrocytes in muscular dystrophy (Rowland (1980) and Plishker and Appel (1980), respectively, for reviews). Takagi et al (1968), Kunze and Olthoff (1970), Hughes (1972) and Kunze et al (1975) have reported changes in the phospholipid composition of dystrophic muscle, but Takagi, Schodand and Rowland (1973) have since stressed the problems arising from the infiltration of the muscle with fat and connective tissue.…”

Section: Introductionmentioning

confidence: 99%

Muscle Lipids in Duchenne Muscular Dystrophy

Pearce

Johnsen

Wysocki

et al. 1981

Aust J Exp Biol Med

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Summary The lipids of muscle and adipose tissue from normal males and of muscle from males with Duchenne muscular dystrophy were investigated. Triglyceride, the major neutral lipid, showed similar fatty acid compositions in all tissues examined. When the phospholipids of dystrophic muscle and of normal adipose tissue were compared with those of normal muscle, it was found that there was an increase in the proportion of sphingomyelin in dystrophic muscle, while adipose tissue had higher proportions of sphingomyelin and lysophosphatidylcholine but lower choline phosphoglyceride. In dystrophic muscle only small alterations from normal were observed in the fatty acid compositions of the individual phospholipids, whereas the phospholipids of adipose tissue had quite distinctive fatty acid compositions. An atrophic muscle sample resulting from poliomyelitis consisted almost entirely of connective tissue and fat and had a phospholipid composition similar to that of adipose tissue. From a comparison of the results for all the types of tissue studied, it is evident that the increase in sphingomyelin in dystrophic muscle biopsies and the changes in the fatty acid compositions of individual phospholipids may be accounted for by the increased amounts of fat and connective tissue which are present in dystrophic muscle samples. In a case each of polymyositis, limb girdle muscular dystrophy and an autosomal recessive form of muscular dystrophy, the results obtained for the phospholipid composition of the muscle sample were also normal or consistent with some contamination from fat and connective tissue.

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“…Our study also failed to provide evidence for significant alterations in Con A and WGA sensitivities of fibroblasts from patients with Duchenne muscular dystrophy, except for that to WGA in one strain. These findings suggest that the abnormal lectin binding in muscle tissues from Duchenne muscular dystrophy is not due to a basic cellular abnormality caused by the mutation, which presumably expressed in the cell membrane of various tissues (Rowland, 1980;Jones and Witkowski, 1983), but merely reflects an effect of increased connective tissues in dystrophic muscle. The reason why one strain is more sensitive to WGA than the strains from the other Duchenne muscular dystrophy patients and the controls is unknown.…”

Section: Discussionmentioning

confidence: 83%

“…Some hereditary muscular dystrophies are believed to be due to defects of the surface of the cell membrane that are also manifested in other than muscle cells (Rowland, 1980;Jones and Witkowski, 1983). Altered carbohydrate compositions have been suggested in muscle cell or erythrocyte membranes from several muscular dystrophies by lectin cytochemistry or biochemical analysis (Bonilla et al, 1978;Dunn et al, 1982;Paljarvi et al, 1984;Capaldi et al, 1984a;Sydow, 1983, 1984).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of lectins toward skin fibroblasts from patients with Duchenne muscular dystrophy and myotonic dystrophy

et al. 1986

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SummaryWe analyzed the cytotoxicities of concanavalin A (Con A) and wheat germ aggulutinin (WGA) toward cultured skin fibroblasts from nine patients with Duchenne muscular dystrophy and four patients with myotonic dystrophy. The survival curves (relative colony-forming ability) of the patient fibroblast strains in the presence of either of the lectins were compared to those of seven normal male human fibroblast strains. The respective mean values for the inverse of the slope of the survival curve (DO) and the concentrations resulting in 10~ (D10) and 1 ~ (D01) survival of each group were compared statistically. The nine Duchenne muscular dystrophy strains showed sensitivities to both Con A and WGA similar to those of the controls, except for the sensitivity to WGA in one strain. The sensitivity to Con A of the four myotonic dystrophy strains was almost the same as that of the controls. However, the survival curves in the presence of WGA suggested that the myotonic dystrophy fibroblasts have hypersensity to higher doses of WGA as compared with the controls.

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Biochemistry of muscle membranes in Duchenne muscular dystrophy

Cited by 261 publications

References 220 publications

Role of Complements and Immunoglobulins in Duchenne Muscular Dystrophy

Role of Complements and Immunoglobulins in Duchenne Muscular Dystrophy

Muscle Lipids in Duchenne Muscular Dystrophy

Cytotoxicity of lectins toward skin fibroblasts from patients with Duchenne muscular dystrophy and myotonic dystrophy

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