Annual Plant Reviews Online 2019
DOI: 10.1002/9781119312994.apr0711
|View full text |Cite
|
Sign up to set email alerts
|

Biochemistry, Genetics, and Genomics of Opium Poppy ( Papaver somniferum ) for Crop Improvement

Abstract: Opium poppy is the only commercially viable source of narcotic raw materials used by the alkaloid pharmaceutical industry. Considerable advances in our knowledge of basic poppy biology and the alkaloid biosynthetic pathway have been driven by recent progress in transcriptomics, genomics, and functional genetics. However, much work remains for this knowledge to be translated into improvements in crop performance. The genetic diversity of poppy is poorly characterised and the available in… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
8
0

Year Published

2021
2021
2023
2023

Publication Types

Select...
3
1

Relationship

4
0

Authors

Journals

citations
Cited by 4 publications
(8 citation statements)
references
References 147 publications
0
8
0
Order By: Relevance
“…; atropine, scopolamine and hyoscyamine from Atropa belladonna). 71,72 Whilst useful pharmaceutically active compounds might then be derived from plants grown in space settlements, two major issues present themselves. The first is that many of the relevant species are unsuitable for compact and intense indoor cultivation.…”
Section: Space Plants Should Have New and Enhanced Functionsmentioning
confidence: 99%
“…; atropine, scopolamine and hyoscyamine from Atropa belladonna). 71,72 Whilst useful pharmaceutically active compounds might then be derived from plants grown in space settlements, two major issues present themselves. The first is that many of the relevant species are unsuitable for compact and intense indoor cultivation.…”
Section: Space Plants Should Have New and Enhanced Functionsmentioning
confidence: 99%
“…The various products of its benzylisoquinoline alkaloid (BIA) pathway have therapeutic uses including for pain relief, in cancer treatment and as cough suppressants [ 66 , 67 ]. Synthesis and accumulation of BIAs occurs in three distinct cells types of poppy capsules; the companion cells, sieve elements and laticifers ( Figure 2b ) [ 68 , 69 ]. Summarised, transcription and translation of the majority of BIA pathway genes take place in the companion cells, then the corresponding functional enzymes (NCS, 6OMT, NMCH, 4′OMT, SalSyn, SalR and SalAT) are exported to sieve elements where alkaloids are synthesised.…”
Section: Tissue-specific Localisation Of Alkaloid Biosynthesis and St...mentioning
confidence: 99%
“…Summarised, transcription and translation of the majority of BIA pathway genes take place in the companion cells, then the corresponding functional enzymes (NCS, 6OMT, NMCH, 4′OMT, SalSyn, SalR and SalAT) are exported to sieve elements where alkaloids are synthesised. Finally, the alkaloids are transported to the laticifers for storage [ 68 , 69 ]. This has been determined by localisation of expression of individual enzymes in the pathway, using biochemical methods.…”
Section: Tissue-specific Localisation Of Alkaloid Biosynthesis and St...mentioning
confidence: 99%
“…Changes in capsule and seed sizes and capsule indehiscence, which is the retention of seed in the capsules, are believed to be among the domestication-related traits in poppy (Zohary et al ., 2012). Currently, poppy is widely cultivated, both as a licit and illicit crop, in Asia, Europe, Oceania and South America as a major source of several benzylisoquinoline alkaloids (BIAs) for the pharmaceutical industry and for the clandestine production of heroin (Beaudoin & Facchini, 2014; Tamiru-Oli et al ., 2018; INCB/UN, 2021). Poppy seeds are also used in the food industry in baking and pressed for extraction of edible oil, while the plant is grown for ornamental purposes in some countries due to its attractive flowers (Labanca et al ., 2018).…”
Section: Introductionmentioning
confidence: 99%
“…Currently, poppy is widely cultivated as both a licit and illicit crop in Asia, Europe, Oceania and South America [8][9][10] . It is a source of several benzylisoquinoline alkaloids (BIAs) including morphine, codeine, thebaine, papaverine and noscapine for the pharmaceutical industry and for the clandestine production of heroin.…”
Section: Introductionmentioning
confidence: 99%