Biochemistry and Pathophysiology of Vanadium

Dafnis, Eugene; Sabatini, Sandra

doi:10.1159/000187913

Cited by 42 publications

(20 citation statements)

References 54 publications

(120 reference statements)

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“…It may serve as an 'endogenous' regulator of Na-K-ATPase with stimulatory effects on adenylate cyclase [119]. Serum vanadium concentrations were extremely high in HD patients, marginally increased in CAPD and almost normal in nondialyzed uremic patients [120,121].…”

Section: Arsenic Cadmium Vanadiummentioning

confidence: 99%

Trace Elements in End-Stage Renal Disease

Zima¹,

Tesař²,

Mestek

et al. 1999

Blood Purif

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For human beings trace elements are essential nutrients with a gamut of functions. They are for instance indispensable components of many enzymes, so they have some regulatory functions and they may affect immune reactions and free radical generation. Abnormalities of trace elements are primarily the result of uremia, and they may be further modified and sometimes greatly exacerbated by the dialysis procedure. The role of trace elements in hemodialysis (HD) patients has not yet been fully characterized. To prevent some complications in chronic HD patients, it is very important to regulate the levels of trace elements by adequate water treatment. Reverse osmosis is able to prevent the accumulation of the majority of trace elements in the patients. Zinc supplementation may be recommended for patients with proven zinc deficiency, but for all chronic renal failure patients it is questionable. Selenium deficiency is to be suspected in dialyzed patients and selenium supplementation may be beneficial (increasing glutathione peroxidase activity, cardioprotective effect, immunostimulatory properties) for chronic renal failure patients. Supplementation with a trace element may be indicated when its depletion was unequivocally documented and when there is evidence of the positive effects of this element on the quality of life of the dialyzed patients.

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Section: Arsenic Cadmium Vanadiummentioning

confidence: 99%

Trace Elements in End-Stage Renal Disease

Zima¹,

Tesař²,

Mestek

et al. 1999

Blood Purif

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“…Vanadium is other metal that alters liver function, inducing ROS via Fenton reaction, damaging proteins and altering the genetic material [167]. Inhalation of V 2 O 5 induces alterations in liver function tests with an increase in ALT y AST, as well as hepatic megalocytosis [168].…”

Section: Metals and Its Toxic Effects On Livermentioning

confidence: 99%

Health Effects of Metals in Particulate Matter

Fortoul¹,

Rodríguez-Lara²,

González-Villalva³

et al. 2015

Current Air Quality Issues

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“…Inhibition of the D-M-induced hyperpolarization by NaAsO 2 involves decreases in R t (Y. Jing and J. S. Fedan, unpublished observations). Although it inhibits the Na ϩ ,K ϩ -pump (Dafnis and Sabatini, 1994), which would lead to depolarization, Na 3 VO 4 increased V t . Na 3 VO 4 had no effect on R t (Y. Jing and J. S. Fedan, unpublished observations); its inhibition of hyperpolarization could result from decreased transcellular ion transport.…”

Section: Kinase Signaling In Airway Responses To Hyperosmolaritymentioning

confidence: 99%

Hyperosmolarity-Induced Dilation and Epithelial Bioelectric Responses of Guinea Pig Trachea in Vitro: Role of Kinase Signaling

Jing

Dowdy²,

Scott³

et al. 2008

J Pharmacol Exp Ther

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Exercise-induced airway obstruction is thought to involve evaporative water loss and hyperosmolarity of the airway surface liquid. Hyperosmolar challenge of the epithelium of isolated, perfused guinea pig trachea rapidly alters transepithelial potential difference (V t ), and it elicits smooth muscle relaxation mediated by epithelium-derived relaxing factor (EpDRF). In many cell types, protein kinases mediate responses to hyperosmolarity and regulatory volume increase. In this study, inhibitors were used to investigate the involvement of kinases and phosphatases in bioelectric responses of epithelium to hyperosmolarity and their possible relationship to EpDRF-mediated relaxation. After contraction of the perfused trachea with extraluminal methacholine, D-mannitol applied intraluminally (Յ80 mosM) increased V t and elicited dilation of the smooth muscle with a similar concentrationdependence; higher concentrations decreased V t . In tracheas exposed to 30 mosM D-mannitol (ϳEC 50 ), 4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)1H-imidazole (SB 203580) and SKF 86002 [6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridyl)imidazo[2,1-b]thiazole] (p38 inhibitors) potentiated the dilation, whereas SP 600125 [anthra[1,9-cd]pyrazol-6(2H)-one-1,9-pyrazoloanthrone] and dicumarol [c-Jun NH 2 -terminal kinase (JNK) inhibitors], chelerythrine [nonselective protein kinase C (PKC) inhibitor], and NaAsO 2 (mitogen-activated protein kinase stress inducer) and Na 3 VO 4 (protein tyrosine phosphatase inhibitor) inhibited the hyperpolarization. Large increases in the phosphorylation of p38 and JNK occurred at concentrations higher than those needed to elicit functional responses. The phosphatidylinositol 3-kinase inhibitor 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY 294002) and Na 3 VO 4 did not affect the V t responses, but they inhibited methacholine-induced constriction; SP 600125 and dicumarol potentiated, and chelerythrine inhibited, methacholine-induced epithelial hyperpolarization. These results suggest that JNK, PKC, and phosphatase(s) are involved in hyperosmolarity-induced hyperpolarization of the tracheal epithelium but that p38 is involved in EpDRF-mediated relaxation.

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Biochemistry and Pathophysiology of Vanadium

Cited by 42 publications

References 54 publications

Trace Elements in End-Stage Renal Disease

Trace Elements in End-Stage Renal Disease

Health Effects of Metals in Particulate Matter

Hyperosmolarity-Induced Dilation and Epithelial Bioelectric Responses of Guinea Pig Trachea in Vitro: Role of Kinase Signaling

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