Biochemistry and Endocrinology of the Down's Syndrome Pregnancy

Chard, Tim

doi:10.1111/j.1749-6632.1991.tb37949.x

Cited by 21 publications

(7 citation statements)

References 80 publications

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“…Our present results, in combination with previous reports, support the hypothesis presented by Chard (1991) suggesting that a generalized placental hypersecretory activity occurs in Down syndrome, and perhaps in Turner syndrome with hydrops. In Down Fig.…”

Section: Discussionsupporting

confidence: 95%

“…Progesterone is a steroid hormone produced by the placenta that is also elevated in second-trimester maternal serum of pregnancies affected with fetal Down syndrome (Knight et al, 1989;Cuckle et al, 1990). Since different cellular mechanisms are required for protein versus steroid synthesis and secretion, these data, taken together, suggest that a generalized placental hypersynthetic and/or hypersecretory phenomenon is associated with this aneuploidy (Chard, 1991).…”

Section: Introductionmentioning

confidence: 93%

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Second-trimester maternal serum progesterone levels in Turner syndrome with and without hydrops and in trisomy 18

et al. 1999

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Section: Discussionsupporting

confidence: 95%

Section: Introductionmentioning

confidence: 93%

Second-trimester maternal serum progesterone levels in Turner syndrome with and without hydrops and in trisomy 18

et al. 1999

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“…Although not measured in the present study, perturbations in maternal serum estriol and hCG levels of mothers carrying fetuses with Down's syndrome have been observed in pregnancies with placental insufficiency and fetal growth retardation [13]. The slightly low er mean birth weight of our infants with Down's syndrome also suggests the presence of chronic in utero fetal hypoxemia.…”

Section: Discussionmentioning

confidence: 65%

Elevated Erythropoietin Levels in Cord Blood of Newborns with Down’s Syndrome

et al. 1994

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Plasma erythropoietin (Ep) was determined in umbilical cord blood in 18 infants with Down’s syndrome. The 16 infants with Down’s syndrome who were delivered after labor had significantly elevated plasma Ep levels compared to 36 control infants born after labor (p < 0.001). Six of the ten infants with Down’s syndrome who had their packed cell volume (PCV) measured in the first 24 h of life were polycythemic based on a PCV of > 0.65. The presence of congenital heart disease in 9 of the 18 infants with Down’s syndrome was not associated with a higher plasma Ep or PCV levels. Plasma Ep was correlated with neonatal PCV in the combined group of control and Down’s syndrome infants (p = 0.003). Increased plasma Ep levels observed in infants with Down’s syndrome suggested chronic fetal hypoxemia as a likely explanation for the high incidence of neonatal polycythemia observed in this group.

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“…Maternal serum PAPP-A ve serbest β-hCG seviyeleri desidulizasyon ve plasentasyon proçesi ile yakın iliş-ki göstermektedir (4) . Birçok faktör bu maddelerin serum seviyelerini etkileyebilmektedir (5) .…”

Section: Introductionunclassified