Biochemistry and Biophysics of Excitation-Contraction Coupling

Fleischer, Sidney; Inui, Makoto

doi:10.1146/annurev.bb.18.060189.002001

Cited by 513 publications

(224 citation statements)

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“…Ryanodine was used at a concentration of 1 μM in these studies as this concentration has previously been demonstrated to activate the channel and stabilize it in a sub-conductance state, whilst higher concentrations lock the channel in a closed state (> 100 μM) (Fleischer and Inui, 1989;Meissner, 1994). Ryanodine had no significant effect on the induction of LTP at this concentration (ryanodine/LTP 155 ± 9%, n = 6, versus control LTP 164 ± 6%, n = 6; Fig.…”

Section: 5mentioning

confidence: 95%

Evidence for a role for the group I metabotropic glutamate receptor in the inhibitory effect of tumor necrosis factor-α on long-term potentiation

Cumiskey¹,

Butler²,

Moynagh³

et al. 2007

Brain Research

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Pro-inflammatory cytokines are known to be elevated in several neuropathological states that are associated with learning and memory. We have previously demonstrated in our laboratory that the inhibition of long-term potentiation (LTP) in the dentate gyrus region of the rat hippocampus, by tumor necrosis factor (TNF)-α, represents a biphasic response, an early phase dependent on p38 mitogen activated protein kinase (MAPK) activation and a later phase, possible dependent on protein synthesis. Many of the factors involved in the early modulation of LTP by TNF-α have yet to be elucidated. This study investigated if metabotropic glutamate receptors (mGluRs) are functionally linked to the inhibitory effect of TNF-α on LTP in the rat dentate gyrus in vitro. We report that the impairment of early-LTP by TNF-α is significantly attenuated by prior application of the group I/II mGluR antagonist MCPG and more specifically the mGluR5 antagonist MPEP. Since TNF-α is now known to cause transient increases in intracellular Ca 2+ levels from ryanodine-sensitive stores, we explored the possibility that disruption of intracellular Ca 2+ homeostasis could be involved.Ryanodine was found to significantly reverse the inhibition of LTP by TNF-α. From these studies we propose that the TNF-α inhibition of LTP is dependent upon the activation of TNFR1 and mGlu5-receptors. Importantly this study provides the first proof of the involvement of ryanodine-sensitive intracellular Ca 2+ stores in TNF-α mediated inhibition of LTP. IntroductionThe pro-inflammatory cytokine tumor-necrosis factor (TNF)-α is elevated in the brain in a number of neuropathological states including trauma, ischemia, Parkinson's disease, multiple sclerosis and HIV-associated dementia (Iida et al., 2000;Kassiotis and Kollias, 2001;Sriram et al., 2002). The signaling mechanism underlying the ability of TNF-α to cause the cognitive dysfunction associated with many of these conditions has been probed, but to date no clear mechanistic understanding has been reached. TNF-α and IL-1β at pathophysiological levels have been shown by many authors to inhibit long-term potentiation (LTP) in the CA1 and the dentate gyrus regions of the rat hippocampus (Cunningham et al., 1996;Murray and Lynch, 1998;Tancredi et al., 1992) but not by others (Stellwagen and Malenka, 2006). IL-1β has been shown to depress NMDAreceptor mediated field potentials in the dentate gyrus (Coogan B R A I N R E S E A R C H 1 1 3 6 ( 2 0 0 7 ) 1 3 -1 9 ⁎ Corresponding author.

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Section: 5mentioning

confidence: 95%

Evidence for a role for the group I metabotropic glutamate receptor in the inhibitory effect of tumor necrosis factor-α on long-term potentiation

Cumiskey¹,

Butler²,

Moynagh³

et al. 2007

Brain Research

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“…In skeletal muscle, the sarcoplasmic reticulum (SR), is so amply developed that it was discovered already at the turn of the century (Veratti, 1902(Veratti, , 1961 (Fleischer and Inui, 1989;Rios et al, 1991). The Ca" channel works as a voltage sensor that triggers activation of the RyR as soon as the sarcolemma is depolarized (Rios et al, 1991).…”

Section: Ca2+ Storesmentioning

confidence: 99%

Endoplasmic reticulum: a dynamic patchwork of specialized subregions.

Sitia

Meldolesi

1992

MBoC

150

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“…Ryanodine receptors are mainly known for their role in regulating calcium release from the sarcoplasmic reticulum of cardiac and skeletal muscle [4][5][6]. A third isoform, RyR3, has been proved to be widely expressed in different tissues and may, therefore, play an important role in calcium homeostasis, also in nonexcitable cells [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%