Biochemische Kontrolle nach konformaler, dreidimensionaler Strahlentherapie des Prostatakarzinoms

Abstract

Despite of having higher initial PSA-values patients treated with conformal radiotherapy and short-term neoadjuvant hormonal therapy had the same bNED survival as patients treated with conformal radiotherapy alone. Patients with initial PSA values above 20 ng/ml, with T3 or T4 disease or with poorly differentiated tumors had a low biochemical control. For this group of patients intensified therapy should be considered.

Regional Hyperthermia in Conjunction with Definitive Radiotherapy against Recurrent or Locally Advanced Prostate Cancer T3 pN0 M0

“…The widespread therapeutic option was radiotherapy alone with radiation doses of 66-70 Gy resulting in a long-term PSA control of only 30% for observation times > 5 years [31]. PSA control in a similar range is achieved for high-risk tumors (e.g., T3/4) by other groups applying standard radiotherapy, e.g., a 5-year PSA control of 35% [28] or a 3-year PSA control of 60% [6]. Therefore, various approaches have been considered to enhance the effectiveness of the standard treatment.…”