Biochemische Grundlagenprozesse im Verlauf der Glaukomerkrankung

Abstract

The term glaucoma summarizes a group of eye diseases that are accompanied by impairments of the optic nerve and related visual field deficits. An early diagnosis of glaucoma is currently not possible due to a lack of diagnostic tests; therefore, in most cases the disease is diagnosed many years after onset, which prevents an early therapy. The known risk factors for the development and progression of glaucomatous optic neuropathy comprise elevated intraocular pressure and a broad range of pressure fluctuations as well as lipometabolic disorders, genetic factor and diabetes. The consequences include the induction of anti-inflammatory proteins, elevated levels of oxidative stress and the destruction of retinal ganglion cells. Changes in the autoantibody repertoire have also been observed in the course of the disease. Basic ophthalmological research therefore focuses on the investigation of basic biochemical processes in the course of the disease. A better understanding of physiological and biochemical events is sought in order to develop new and more sensitive diagnostic options and to allow more targeted therapeutic measures. The understanding of biochemical processes allows a better insight into glaucoma progression to be gained, which will lead to improvements in diagnosis and therapy.

Psychosomatic Aspects in Preparation and Follow-Up in Glaucoma Surgery and Their Special Impact on Patients

“…Da die Optikusneuropathie ein schleichender Prozess ist mit unaufhörlichem Untergang der retinalen Ganglienzellen [21], ist eine Zielorientierung wichtig: Frühdiagnostik und Zieldruckwerte; ebenso dieses tröstend und Hoffnung gebend im Gespräch, in der Kommunikation von Arzt zu Patient, zu vermitteln [22,23].…”

“…Bitte fragen Sie die Patienten explizit nach solchen Veränderungen, um ein verbessertes Behandlungskonzept zu erstellen, aufzuklären und den Lebenspartner oder die Familie mit einzubeziehen [22].…”