Biochemicals Associated With Pain and Inflammation are Elevated in Sites Near to and Remote From Active Myofascial Trigger Points

Shah, Jay P.; Danoff, Jerome V.; Desai, Mehul; Parikh, Sagar S.; Nakamura, Lynn Y.; Phillips, Terry M.; Gerber, Lynn H.

doi:10.1016/j.apmr.2007.10.018

Cited by 624 publications

(443 citation statements)

References 18 publications

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“…The concentration of selected inflammatory mediators, neuropeptides, cytokines and catecholamines also differ quantitatively from a remote, uninvolved site (32).…”

Section: Discussionmentioning

confidence: 99%

Impact of nervous system hyperalgesia on pain, disability, and quality of life in patients with knee osteoarthritis: A controlled analysis

Imamura¹,

Imamura²,

Kaziyama³

et al. 2008

Arthritis & Rheumatism

274

245

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Objective. Refractory, disabling pain associated with knee osteoarthritis (OA) is usually treated with total knee replacement. However, pain in these patients might be associated with central nervous sensitization rather than peripheral inflammation and injury. We evaluated the presence of hyperalgesia in patients scheduled for a total knee replacement due to knee osteoarthritis with refractory pain, and we assessed the impact of pressure pain threshold measurements (PPT) on pain, disability, and quality of life of these patients. Methods. Sixty-two female patients were compared with 22 age-matched healthy controls without reported pain for the last year. PPT was measured at the lower extremities subcutaneous dermatomes, over the vastus medialis, adductor longus, rectus femoris, vastus lateralis, tibialis anterior, peroneus longus, iliacus, quadratus lumborum and popliteus muscles and at the supraspinous ligaments from L1-L5, over the L5-S1 and S1-S2 sacral areas and at the pes anserinus bursae and patellar tendon. Results. Patients with knee OA had significantly lower PPT over all evaluated structures versus healthy control subjects (P < 0.001). Lower PPT values were correlated with higher pain intensity, higher disability scores, and with poorer quality of life, except for the role-emotional and general health status. Combined PPT values over the patellar tendon, at the S2 subcutaneous dermatome and at the adductor longus muscle were the best predictors for visual analog scale and Western Ontario and McMaster Universities Osteoarthritis Index pain scores. Conclusion. Patients with pain due to osteoarthritis who were scheduled for total knee replacement showed hyperalgesia of nervous system origin that negatively impacted pain, knee functional capacity, and most aspects of quality of life.

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“…The concentration of selected inflammatory mediators, neuropeptides, cytokines and catecholamines also differ quantitatively from a remote, uninvolved site (32).…”

Section: Discussionmentioning

confidence: 99%

Impact of nervous system hyperalgesia on pain, disability, and quality of life in patients with knee osteoarthritis: A controlled analysis

Imamura¹,

Imamura²,

Kaziyama³

et al. 2008

Arthritis & Rheumatism

274

245

View full text Add to dashboard Cite

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“…The prevalence of trigger point varies from 21% of patients seen in a general orthopedic clinic, to 30% of general medical clinic patients with regional pain, to as high as 85% to 93% of patients presenting to specialty pain management centers. 5,6 It has detrimental effects on people's social and work-related activities, has a significant impact on the quality of life, and causes pain and functional disability in the neck and shoulder areas. 2,3 Some chemical changes, such as increased levels of bradykinin, substance P, and calcitonin gene-related peptide and lowered pH, have been reported in MTP.…”

Section: Introductionmentioning

confidence: 99%

Clinical Effectiveness of Dry Needling Immediately After Application on Myofascial Trigger Point in Upper Trapezius Muscle

Ziaeifar

Arab

Nourbakhsh

2016

Journal of Chiropractic Medicine

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Objective: The purpose of this study was to investigate the effect of dry needling (DN) on pain intensity and pressure pain threshold (PPT) compared with ischemic compression (IC) immediately and 48 hours after each treatment session in individuals with myofascial trigger points in the upper trapezius muscle. Methods: Thirty-one patients with myofascial trigger points in the upper trapezius muscle participated in this study. Patients were randomly assigned to a standard (N = 17) or experimental group (N = 14). The treatment protocol for the standard group consisted of IC, whereas the patients in the experimental group received DN. Results: The results indicated that the effect size of the DN methods for pain intensity and PPT was considerably greater after 2 days compared with immediately after the treatment session. In contrast, the effect of the IC for PPT was greater immediately after treatment compared with the measures after 2 days. There was also no noticeable difference in the effect size for IC on pain intensity between the scores obtained immediately and 2 days after treatment. However, our data also revealed a greater effect size for DN on PPT after 2 days compared with the IC technique. Conclusions: In this study, DN improved the pain intensity and PPT after 2 days. However, it had no clinical improvement immediately after application because of muscle soreness. Thus, assessment of the effect of DN immediately after application can be criticized, and the results should be interpreted with caution. (J Chiropr Med 2016;15:252-258)

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“…The authors raise the hypothesis that this is due to a sarcometric contraction of the muscle fibers, a reduction in blood flow and consequent local hypoxia. 41,51 The authors also suggest that their findings confirm the usefulness of thermography in the evaluation of pain in the masticatory muscles, especially when used as a physical examination in conjunction with complementary exams.…”

Section: Discussionmentioning

confidence: 62%

“…24,39 For the specific evaluation of pain, algometry is considered the standard of reference in the literature. 40,41 Visscher, et al 42 concluded that the use of algometry in the identification of pain complaints in TMD is comparable to manual palpation. In the proposed study, the decision was made to evaluate pain through both algometry and manual palpation (recommended in the RDC/TMD) for greater reliability in the results.…”

Section: Discussionmentioning

confidence: 99%

Influence of Phototherapy on Thermographic Images and Pain in Individuals with Temporomandibular Disorder: Protocol for a Randomized, Placebo-Controlled, Double-Blind Clinical Trial

Tosato¹,

Herpich²,

Leal-Junior³

et al. 2015

Dent Open J

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Biochemicals Associated With Pain and Inflammation are Elevated in Sites Near to and Remote From Active Myofascial Trigger Points

Cited by 624 publications

References 18 publications

Impact of nervous system hyperalgesia on pain, disability, and quality of life in patients with knee osteoarthritis: A controlled analysis

Impact of nervous system hyperalgesia on pain, disability, and quality of life in patients with knee osteoarthritis: A controlled analysis

Clinical Effectiveness of Dry Needling Immediately After Application on Myofascial Trigger Point in Upper Trapezius Muscle

Influence of Phototherapy on Thermographic Images and Pain in Individuals with Temporomandibular Disorder: Protocol for a Randomized, Placebo-Controlled, Double-Blind Clinical Trial

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