Biochemical (T2, T2* and magnetisation transfer ratio) MRI of knee cartilage: feasibility at ultra-high field (7T) compared with high field (3T) strength

Welsch, Goetz H.; Apprich, Sebastian; Zbýň, Štefan; Mamisch, Tallal C.; Mlynarik, Vladimir; Scheffler, Klaus; Bieri, Oliver; Trattnig, Siegfried

doi:10.1007/s00330-010-2029-7

Cited by 69 publications

(66 citation statements)

References 32 publications

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“…Although these studies indicate that the observed T 2 is independent of magnetic field strength, more recent work in musculoskeletal tissues has found that T 2 typically decreases with increasing magnetic field strength 4–7 . Thus in our experiment, we expect T 1 to increase substantially and T 2 to decrease slightly at 7.0T compared to the relaxation times at 3.0T 5, 7 .…”

Section: Introductionmentioning

confidence: 84%

Musculoskeletal MRI at 3.0T and 7.0T: A comparison of relaxation times and image contrast

Jordan

Saranathan

Bangerter

et al. 2013

European Journal of Radiology

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OBJECTIVE The purpose of this study was to measure and compare the relaxation times of musculoskeletal tissues at 3.0T and 7.0T, and to use these measurements to select appropriate parameters for musculoskeletal protocols at 7.0T. MATERIALS AND METHODS We measured the T1 and T2 relaxation times of cartilage, muscle, synovial fluid, bone marrow and subcutaneous fat at both 3.0T and 7.0T in the knees of five healthy volunteers. The T1 relaxation times were measured using a spin-echo inversion recovery sequence with six inversion times. The T2 relaxation times were measured using a spin-echo sequence with seven echo times. The accuracy of both the T1 and T2 measurement techniques was verified in phantoms at both magnetic field strengths. We used the measured relaxation times to help design 7.0T musculoskeletal protocols that preserve the favorable contrast characteristics of our 3.0T protocols, while achieving significantly higher resolution at higher SNR efficiency. RESULTS The T1 relaxation times in all tissues at 7.0T were consistently higher than those measured at 3.0T, while the T2 relaxation times at 7.0T were consistently lower than those measured at 3.0T. The measured relaxation times were used to help develop high resolution 7.0T protocols that had similar fluid-to-cartilage contrast to that of the standard clinical 3.0T protocols for the following sequences: proton-density-weighted fast spin-echo (FSE), T2-weighted FSE, and 3D-FSE-Cube. CONCLUSION The T1 and T2 changes were within the expected ranges. Parameters for musculoskeletal protocols at 7.0T can be optimized based on these values, yielding improved resolution in musculoskeletal imaging with similar contrast to that of standard 3.0T clinical protocols.

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Section: Introductionmentioning

confidence: 84%

Musculoskeletal MRI at 3.0T and 7.0T: A comparison of relaxation times and image contrast

Jordan

Saranathan

Bangerter

et al. 2013

European Journal of Radiology

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“…The T2 values for healthy volunteers in this study (43.6 ms to 56.6 ms) are similar to values obtained with the volume coil in our study (9). In 2010, Welsch evaluated patellar cartilage T2 values using a surface coil at 3T and 7T (18). The T2 values obtained at 7T in this later study (mean 41.8 ms) were slightly lower than the ones reported in his 2008 volume coil study.…”

Section: Discussionmentioning

confidence: 99%

Comparison of a 28‐channel receive array coil and quadrature volume coil for morphologic imaging and T2 mapping of knee cartilage at 7T

Chang

Wiggins

Xia

et al. 2011

Magnetic Resonance Imaging

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Purpose To compare a new birdcage-transmit, 28 channel-receive array (28 Ch) coil and a quadrature volume coil for 7 Tesla morphologic MRI and T2 mapping of knee cartilage. Methods The right knees of ten healthy subjects were imaged on a 7 Tesla whole body MR scanner using both coils. 3-dimensional fast low-angle shot (3D-FLASH) and multi-echo spin-echo (MESE) sequences were implemented. Cartilage signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), thickness, and T2 values were assessed. Results SNR/CNR was 17–400% greater for the 28 Ch compared to the quadrature coil (p≤0.005). Bland-Altman plots show mean differences between measurements of tibial/femoral cartilage thickness and T2 values obtained with each coil to be small (−0.002±0.009 cm/0.003±0.011 cm) and large (−6.8±6.7 ms/−8.2±9.7 ms), respectively. For the 28 Ch coil, when parallel imaging with acceleration factors (AF) 2, 3, and 4 was performed, SNR retained was: 62–69%, 51–55%, and 39–45%. Conclusion A 28 Ch knee coil provides increased SNR/CNR for 7T cartilage morphologic imaging and T2 mapping. Coils should be switched with caution during clinical studies because T2 values may differ. The greater SNR of the 28 Ch coil could be used to perform parallel imaging with AF2 and obtain similar SNR as the quadrature coil.

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“…Although the difficulty to depict cartilage by MRI is well known [38], newer imaging modalities such as 7T MRI may overcome this impediment [39].…”

Section: Imagingmentioning

confidence: 99%

Monitoring rheumatoid arthritis

Smolen

Aletaha

2011

Current Opinion in Rheumatology

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Biochemical (T2, T2* and magnetisation transfer ratio) MRI of knee cartilage: feasibility at ultra-high field (7T) compared with high field (3T) strength

Abstract: Although lower T2 and T2* relaxation times were expected at 7T, the differences in stratification between the field strengths were reported for the first time. The assessment of MT is feasible at 7T, but requires further investigation.

Cited by 69 publications

References 32 publications

Musculoskeletal MRI at 3.0T and 7.0T: A comparison of relaxation times and image contrast

Musculoskeletal MRI at 3.0T and 7.0T: A comparison of relaxation times and image contrast

Comparison of a 28‐channel receive array coil and quadrature volume coil for morphologic imaging and T2 mapping of knee cartilage at 7T

Monitoring rheumatoid arthritis

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