Biochemical Study On the Effect of Morin and Rutin in amelioration of Titanium dioxide Nanoparticle Toxicity in rat liver

Sherif, Mohamed H.; Hussein, Mohamed M. A.; ##Eid, Reham; Abas, Al-Shimaa M.

doi:10.21608/blj.2019.63834

Cited by 4 publications

(5 citation statements)

References 20 publications

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“…Also, the results showed a significant decrease in the level of MDA in the two groups (G3) treated with rutin at a concentration of 60 mg/kg with H2O2 and (G4) treated with rutin at a concentration of 30 mg/kg with H2O2, compared to the positive control group (G2). These results are in line with the findings of both researchers [37], [41], where rutin works to break the activation chain of free radicals, inhibits lipid peroxidation activity and free radical production, and reduces the final products of lipid peroxidation [42]. The results also showed a significant decrease in the level of MDA for the (G5) treated with rutin at a concentration of 60 mg / kg and (G6) treated with rutin at a concentration of 30 mg / kg compared with the negative control group (G1).…”

Section: Discussionsupporting

confidence: 93%

“…Also, rutin has an inhibitory effect on the enzyme Xanthine oxidase involved in the generation of free radicals [34]. The antioxidant activity of rutin is attributed to its chemical composition that enables it to scavenge free radicals with high efficiency [32], and rutin helps to increase the production of glutathione and the cellular protection system [33], and rutin has an inhibitory effect on the enzyme Xanthine oxidase involved in the generation of free radicals [34] These results are in agreement with the researchers' studies [35]- [37].…”

Section: Discussionsupporting

confidence: 82%

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Effect of Rutin on the Histological Structure of the Heart and Some Biochemical Indicators of Oxidative Stress in Male Albino Rats

Hussani¹,

Sabour²

2022

PJMHS

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The current study aimed to know the effect of rutin at a dose of (30 mg/kg of body weight) and (60 mg/kg of body weight) on heart tissues in two groups of normal rats and two groups of rats exposed to oxidative stress with 1% hydrogen peroxide for the duration of the experiment., as well as the effects of rutin on the percentage of some antioxidants such as glutathione GSH, and the percentage of malonaldehyde (MDA) in the serum. (48) male rats were used, they were divided into six groups.: the first group (control) included eight males, and the second group hydrogen peroxide H2O2 1%, H2O2, and rutin at a concentration of 60 mg/kg, H2O2 with a concentration of rutin 30 mg/kg, and with a concentration of rutin at a concentration of 60 mg/kg and with a concentration of 30 mg/kg of rutin. All groups dosed daily for one month, after taking blood samples, sacrificing the animals, and making tissue sections of the heart under study. The results revealed that Rutin increased the GSH glutathione ratio in the groups in which oxidative stress was induced by hydrogen peroxide by 1% compared to the control group treated with hydrogen peroxide only. While rutin reduced MDA in the same groups compared to the control group that was treated with hydrogen peroxide by only 1%. At (P≤ 0.05) The histological study of the heart of mice treated with Rutin revealed a high cure rate, as Rutin showed protection of the heart tissue from the toxicity caused by hydrogen peroxide. While the tissue sections of the positive control group that were treated with 1% hydrogen peroxide showed clear tissue degeneration with hemorrhage and necrosis. The histological results of two groups treated with concentrations of (30 mg/kg of body weight) and (60 mg/kg of body weight) showed no toxic effects of rutin compared with the negative control group. Keywords: Rutin, heart, GSH, MDA

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 82%

Effect of Rutin on the Histological Structure of the Heart and Some Biochemical Indicators of Oxidative Stress in Male Albino Rats

Hussani¹,

Sabour²

2022

PJMHS

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“…Additionally, the active constituent Rutin could in uence the inhibition of some cancers due to its antioxidant, anti-angiogenic, antiallergic, anti-in ammatory, and antiviral property [74]. Naringenin, dietary avonoid, improved the physiological alternations caused by isoniazid certain metabolic alteration that declared anti-in ammatory and anti-oxidative properties [75].…”

Section: Discussionmentioning

confidence: 99%

Ki-67 pulmonary Immunoreactivity in silver nanoparticles toxicity: size-rate dependent genotoxic impact

Ali

Kadry

Hammam

et al. 2022

Preprint

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BackgroundEngineered nanoparticles have been recently utilized in numerous domains particularly, silver nanoparticles (AgNPs). Nonetheless, the possible side effects resulting from AgNPs exposure are not fully clarified. The present study aimed to clarify the toxicity of AgNPs toxic effect on lung tissue. This study was extended to investigate the impact of Glycosmis pentaphylla (G. pentaphylla) and Casimiroa edulis (C. edulis) leaves extracts in addition to mucilage and protein; the purified compounds from C. edulis against AgNPs induced pulmonary toxicity. MethodsMale Swiss albino mice were administered AgNPs orally in two different particle sizes (20 nm and 100 nm) for one month and was further treated via the above mentioned natural product extracts in a dose of 500 mg/ kg for three weeks. Biochemical, molecular, immunohistochemistry, and histopathological investigations were further assessed. ResultsOur results declared an obvious alternation in oxidative stress biomarkers as well as mRNA gene expression of both survivin and matrix metalloproteinase (MMP-9) in addition to exploration of positive nuclei for ki-67. Data declared a significant upregulation of both glutathione s transferase and superoxide dismutase antioxidants up on treatment by C. edulis extract. Furthermore, a remarkable downregulation of MMP-9as well as survivin mRNA gene expression in all treated groups. Immunohistopathological examination investigated a significant improvement in the reactivity of ki-67 biomarker upon treatment. Histopathlgical examination confirmed the obtained results.ConclusionIn conclusion; these functional foods extracts could be considered as a promising candidate as therapeutic regimen against pulmonary toxicity induced via Ag-NPs due to their enrichment with different active constituents.

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“…Additionally, the active constituent rutin could influence the inhibition of some cancers due to its antioxidant, anti-angiogenic, antiallergic, anti-inflammatory, and antiviral properties [61] . Naringenin, a dietary flavonoid, improved the physiological alternations caused by isoniazid, certain metabolic alteration that declared anti-inflammatory and anti-oxidative properties [1] .…”

Section: Discussionmentioning

confidence: 99%

Ki-67 pulmonary immunoreactivity in silver nanoparticles toxicity: Size-rate dependent genotoxic impact

Ali¹,

Kadry²,

Hammam

et al. 2022

Toxicology Reports

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Biochemical Study On the Effect of Morin and Rutin in amelioration of Titanium dioxide Nanoparticle Toxicity in rat liver

Cited by 4 publications

References 20 publications

Effect of Rutin on the Histological Structure of the Heart and Some Biochemical Indicators of Oxidative Stress in Male Albino Rats

Effect of Rutin on the Histological Structure of the Heart and Some Biochemical Indicators of Oxidative Stress in Male Albino Rats

Ki-67 pulmonary Immunoreactivity in silver nanoparticles toxicity: size-rate dependent genotoxic impact

Ki-67 pulmonary immunoreactivity in silver nanoparticles toxicity: Size-rate dependent genotoxic impact

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