Biochemical study of lipoprotein lipase enzyme and apo-lipoprotein-C2 in patients with and without type 2 diabetes mellitus

Abstract

Type two diabetes mellitus (T2DM) is the most common type of diabetes; it is characterized by hyperglycemia in the presence of hyperinsulinemia which is produced from beta cell insulin secretory malfunction and insulin resistance. This study was designed as a case-control study and was constructed to study the effect of type 2 diabetes mellitus on lipoprotein lipase and Apo lipoprotein C2 levels among lipid profiles in type 2 diabetes. The patient's ages ranged from (40-60) years. The serum sample of all groups was collected and used to measure the level of lipoprotein lipase and Apo lipoprotein C2 by using the ELISA method and to measure lipid profile by spectrophotometer technique. All samples were collected from Merjan Medical City at Babylon/ Hilla city. The study revealed that there was a significant decrease in the levels of lipoprotein lipase in patients with type 2 diabetes mellitus compared with the control group ( P < 0.001), also there was a significant increase in the levels of Apo lipoprotein C2 in the patient’s group compared with the control group ( P= 0.02).