Biochemical Studies On The Effect of Plotosus Lineatus Crude Venom (In Vivo) And Its Effect On Eac-Cells (In Vitro)

Fahim, Fawzia A.; Mady, Essam; Ahmed, Somia B.; Zaki, M. A.

doi:10.1007/978-1-4613-0361-9_28

Cited by 9 publications

(5 citation statements)

References 15 publications

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“…The venom of the oriental catfish, P. lineatus, is cytotoxic to a number of cell types, including cultured Ehrlichs ascites tumour cells (Fahim et al. 1996).…”

Section: Bioactivity Of Piscine Venomsmentioning

confidence: 99%

“…The neuromuscular properties of fish venom have been well studied. Most piscine venom produces neurotoxic symptoms such as paralysis, convulsions, and muscular weakness and at higher doses respiratory cessation, which leads to death, when injected into experimental animals (Saunders 1959;Saunders and Taylor 1959;Weiner 1959;Austin et al1961;Nair et al 1985;Fahim et al 1996;Breton et al 1999;Carrijo et al 2005;Sivan et al 2007). All piscine venoms act both prejunctionally and post-junctionally to produce depolarization of cell membranes (Church and Hodgson 2002).…”

Section: Neuromuscular Activitymentioning

confidence: 99%

“…The venom of the oriental catfish, P. lineatus, is cytotoxic to a number of cell types, including cultured Ehrlichs ascites tumour cells (Fahim et al 1996). The cytotoxic effect of fish venom on cultured myoblast endothelial cells, mononuclear cell lines (J774A1), have been studied (Lopes-Ferreira et al 2001.…”

Section: Cytolytic Activitymentioning

confidence: 99%

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Fish venom: pharmacological features and biological significance

Sivan¹

2009

Fish and Fisheries

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Nearly 1200 species of marine fish are venomous and they account for two‐third of the population of venomous vertebrates. Fish venoms are focused as a potential source of pharmacological agents and physiological tools that have evolved to target vital processes in the human body that appear to have more electivity than many drugs. Fish venoms possess cardiovascular, neuromuscular, oedematic and cytolytic activity. Lethal toxins have been isolated and purified, with some having LD50 values comparable to that of snake venoms. Cardiovascular activity seems to be the dominant effect of fish venoms in experimental models. Piscine venom acts both pre‐ and post‐junctionally to produce depolarization of cell membranes. Studies on cytolytic activity of fish venom found that it produces lysis by forming hydrophilic pores in cell membranes which then result in cell lysis. Almost all fish venoms with neuromuscular activity also possesses cytolytic activity, and it is very likely that the two activities are related. Fish venom is known to induce intense and sustained edematogenic response. As piscine venoms have evolved for the same purpose, they show a number of similarities pharmacologically and it seems likely that most of the biological activities of any given toxin can be traced back to its cytolytic activity. A variety of toxins have been isolated from piscine venom. Although there is a complex balance between the components present in the venom of different fish, all of them seem to share similar activity – functionally and pharmacologically as well as structurally.

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“…The venom of the oriental catfish, P. lineatus, is cytotoxic to a number of cell types, including cultured Ehrlichs ascites tumour cells (Fahim et al. 1996).…”

Section: Bioactivity Of Piscine Venomsmentioning

confidence: 99%

Section: Neuromuscular Activitymentioning

confidence: 99%

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Fish venom: pharmacological features and biological significance

Sivan¹

2009

Fish and Fisheries

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“…Vale ressaltar que a peçonha do bagre H. fossilis também produz uma importante resposta hipotensiva (DATTA et al, 1982) ao contrário da peçonha de P. canius que produz resposta hipertensiva in vivo (AUDDY et al, 1994). Sintomas neurotóxicos foram induzidos pela peçonha de P. lineatus quando administrada intraperitonealmente em camundongos (FAHIM et al, 1996). A atividade hemolítica foi detectada nos venenos de P. canius e H. fossilis, enquanto a peçonha do bagre P. lineatus mostrou-se citotóxica para células tumorais de Ehrlish (FAHIM et al, 1996).…”

Section: Estudos Importantes Foram Realizados Com Peçonhas Dos Bagresunclassified

“…Sintomas neurotóxicos foram induzidos pela peçonha de P. lineatus quando administrada intraperitonealmente em camundongos (FAHIM et al, 1996). A atividade hemolítica foi detectada nos venenos de P. canius e H. fossilis, enquanto a peçonha do bagre P. lineatus mostrou-se citotóxica para células tumorais de Ehrlish (FAHIM et al, 1996).…”

Section: Estudos Importantes Foram Realizados Com Peçonhas Dos Bagresunclassified