Biochemical studies on copper, copper oxidase, magnesium, sulfur, calcium and phosphorus in cancer of the breast

Jorge, F.E.; Góes, J.C.; Guedes, J.L.; Cintra, André

doi:10.1016/0009-8981(65)90127-0

Cited by 38 publications

(10 citation statements)

References 5 publications

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“…Some authors, however, represent a different point of view [6,7,9]. Data on Mg concentration in cancerous tissues gathered in 1950s and 1960s are at variance with those which we obtained [3,8]. It seems likely that the low selectivity methods employed by these authors did not guarantee clear-cut separation of Mg from other cat ions and anions in the assay.…”

Section: Discussioncontrasting

confidence: 54%

Red Blood Cell, Serum and Tissue Magnesium Levels in Subjects with Laryngeal Carcinoma

Szmeja¹,

Kończewska²

1983

ORL

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Red blood cell, serum and tissue Mg concentrations in 100 subjects with aged 34–78, with squamous cell carcinoma of the larynx were determined by atomic absorption spectrophotometry. The concentration of this cation in cancerous tissues was found to be about twice as high as in the unchanged homologous tissues of the host. This was accompanied by a systemic deficiency manifesting itself by a decreased Mg concentration in red blood cells, serum and muscles which became more pronounced as the disease advanced, and returned to normal after radical treatment.

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Section: Discussioncontrasting

confidence: 54%

Red Blood Cell, Serum and Tissue Magnesium Levels in Subjects with Laryngeal Carcinoma

Szmeja¹,

Kończewska²

1983

ORL

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“…Margalioth and coworkers [72] have observed that there are no differences significantly between Cu concentrations in cancerous (malign) and normal breast tissues, whereas Geraki and coworkers [68,[73][74] reported that Cu levels in cancerous breast tissues were 4.5-fold higher than that in healthy breast for both paired and independent samples. Furthermore, 10-fold higher concentrations by Jorge and coworkers [75] and higher results by Garg [69] and Kuo [71] and their coworkers were reported as related to the increase in Cu concentrations in cancerous breast tissues when compared to non-cancerous tissues. The mechanism of copper elevation in cancerous tissues is not clearly known.…”

Section: Breast Tissuementioning

confidence: 85%

Comprehensive Comparison of Trace Metal Concentrations in Cancerous and Non-Cancerous Human Tissues

Yaman

2006

CMC

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The roles of metals in the development and inhibition of cancer have a complex character and have risen many questions because of their essential and toxic effects on human health. Question of whether trace metal concentrations in tissues are increased or decreased in cancerous patients in comparison with non-cancerous patients has not been answered yet, due to the fact that the data known in this field is rare and have contradictory results. Although Zn and Cu concentrations in serum and tissues of cancerous patients have been extensively studied, the precise role of these metals in carcinogenesis is not clearly understood. On the other hand, the comprehensive review on trace metal concentrations in cancerous and non-cancerous tissues is uncommon. The differences in literature on the increases or decreases in trace metal concentrations of cancerous tissues in comparison with non-cancerous tissues may be attributed to a few reasons such as the tissue basis-dry or wet weight, different sensitivities and basis of analysis methods that affect the accuracy, and the difficulties in taking of the sample representing the cancerous or non-cancerous area. In this study, the data published up to now have been reviewed. Comparison of results was done according to tissue and cancer types and trace metal species. The probable causes of differences in literature data were discussed. Especially, the published studies in recent years needed such a review.

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“…(16), which may indicate a higher metastatic potential (17). Several studies concerning the concentration of Cu or Zn in various malignant tissues have been carried out (34)(35)(36)(37)(38). Cu contents in malignant tissues, such as breast cancers (40,41) and malignancies of the large bowel, stomach, and female reproductive system, are relatively greater than those in corresponding non-malignant tissues (42).…”

Section: Lmrnunohistochemical Expression Of Metallothionein and Concementioning

confidence: 99%

Metallothionein expression and concentrations of copper and zinc are associated with tumor differentiation in hepatocellular carcinoma

Tashiro‐Itoh

Ichida

Matsuda

et al. 1997

Liver

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Metallothionein is the carrier protein of heavy metal ions, such as copper (Cu) and zinc (Zn). In this study, the relationships among immunohistochemical expression of metallothionein, concentrations of Cu and Zn, histological differentiation and proliferative activity of hepatocellular carcinoma were investigated in 5 1 cases. The concentrations of Cu and Zn in both tumor and non-tumor tissues were determined using electron probe microanalysis. Immunohistochemical expression of metallothionein in tumor tissues decreased with the degree of differentiation, whereas the number of hepatocytes positive for Ki-67 increased. Furthermore, the concentrations of Cu and Zn in tumor tissues decreased with the degree of histological differentiation in human hepatocellular carcinoma.Metallothionein, a low molecular weight protein with a high content of cysteine, exhibits selective binding affinity for heavy metal ions (1). Metallothionein appears to play a homeostatic role in the control of extracellular zinc and detoxification of copper and cadmium (2), and also supplies copper and zinc to enzymes which require them as co-factors. Furthermore, metallothionein is a scavenger of free hydroxyl (. OH) and superoxide (02-) radicals, which are produced after various stresses such as X-ray irradiation, exposure to high-pressure oxygen and alkylating agents, and infection (3-6).Previous reports have shown a relationship between metallothionein and the degree of malignancy (7-9). Immunohistochemical over-expression of metallothionein has been demonstrated in a variety of human malignancies such as carcinoma of the thyroid, testicular embryonal carcinoma, and adenocarcinoma of the breast (7-14).On the other hand, reduced expression of metallothionein has been demonstrated by immunohistochemistry in liver tumors (15) and colorectal adenocarcinomas (16). It has been reported that immunohistochemical expression of metallothionein correlates significantly with the tumor stage in colorectal carcinoma (17). However, the relationship between immunohistochemical expression of metallothionein and differentiation in hepatocellular carcinoma has not been clarified. Therefore, the purpose of this study was to examine the relationship between immunohistochemical expression of metallothionein and histological differentiation of hepatocellular carcinoma. Proliferative activity of tumor cells was evaluated using immunohistochemical staining for 19). Furthermore, the concentrations of Cu and Zn, which bind to metallothionein and are necessary as co-factors (20), were evaluated using electron probe microanalysis (21). 300

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Biochemical studies on copper, copper oxidase, magnesium, sulfur, calcium and phosphorus in cancer of the breast

Cited by 38 publications

References 5 publications

Red Blood Cell, Serum and Tissue Magnesium Levels in Subjects with Laryngeal Carcinoma

Red Blood Cell, Serum and Tissue Magnesium Levels in Subjects with Laryngeal Carcinoma

Comprehensive Comparison of Trace Metal Concentrations in Cancerous and Non-Cancerous Human Tissues

Metallothionein expression and concentrations of copper and zinc are associated with tumor differentiation in hepatocellular carcinoma

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