Biochemical studies in the vole, Microtus montanus—II. The effects of a Trypanosoma brucei gambiense infection on the diurnal variation of hepatic glucose-6-phosphatase and liver glycogen

Ashman, Portia U.; Seed, John

doi:10.1016/0305-0491(73)90072-2

Cited by 8 publications

(4 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3F). An animal study conducted in voles confirmed the model prediction (2). When G6Pase activity was measured over a 24-h period, animals in constant dark environment showed statistically significant oscillation, whereas the animals in constant light environment did not.…”

Section: Resultssupporting

confidence: 61%

“…2F) also peaks in the early active phase according to our model. In ad libitum fed rats, both G6Pase and PEPCK activity peak slightly before the dark (active) phase in rats subjected to 12:12-h light-dark cycle (2,32). When rats are moved to TRF schedule, G6Pase activity peaks slightly before the feeding start time.…”

Section: Resultsmentioning

confidence: 99%

“…corticotrophin-releasing hormone (CRH), ACTH, and cortisol are modeled with a Goodwin oscillator modified with Michaelis-Menten kinetics with self-sustained oscillations, entrained by the light-dark cycle (Eqs. [2][3][4]. Estimated parameter values and descriptions are reported in Table 1 in the repository (see ENDNOTE).…”

Section: Incorporation Of Environmental Signalsmentioning

confidence: 99%

See 2 more Smart Citations

Mathematical analysis of circadian disruption and metabolic re-entrainment of hepatic gluconeogenesis: the intertwining entraining roles of light and feeding

Bae

Androulakis

2018

American Journal of Physiology-Endocrinology and Metabolism

View full text Add to dashboard Cite

The circadian rhythms influence the metabolic activity from molecular level to tissue, organ, and host level. Disruption of the circadian rhythms manifests to the host's health as metabolic syndromes, including obesity, diabetes, and elevated plasma glucose, eventually leading to cardiovascular diseases. Therefore, it is imperative to understand the mechanism behind the relationship between circadian rhythms and metabolism. To start answering this question, we propose a semimechanistic mathematical model to study the effect of circadian disruption on hepatic gluconeogenesis in humans. Our model takes the light-dark cycle and feeding-fasting cycle as two environmental inputs that entrain the metabolic activity in the liver. The model was validated by comparison with data from mice and rat experimental studies. Formal sensitivity and uncertainty analyses were conducted to elaborate on the driving forces for hepatic gluconeogenesis. Furthermore, simulating the impact of Clock gene knockout suggests that modification to the local pathways tied most closely to the feeding-fasting rhythms may be the most efficient way to restore the disrupted glucose metabolism in liver.

show abstract

Section: Resultssupporting

confidence: 61%

Section: Resultsmentioning

confidence: 99%

Section: Incorporation Of Environmental Signalsmentioning

confidence: 99%

See 1 more Smart Citation

Mathematical analysis of circadian disruption and metabolic re-entrainment of hepatic gluconeogenesis: the intertwining entraining roles of light and feeding

Bae

Androulakis

2018

American Journal of Physiology-Endocrinology and Metabolism

View full text Add to dashboard Cite

show abstract

“…Trypanosomes have been reported to destroy blood glucose due to aerobic glycolysis (16). The organism metabolizes glucose to produce 4-hydroxy-4-methyl α-ketogluterate, which is inhibitory to the tricarboxylic acid cycle (TCA) in the mitochondria leading to energy deficit in the host (6,16). This suggests that TCA and oxidative phosphorylation may be inhibited, thus leading to failure to generate energy from energy-rich compounds.…”

Section: ■ Discussionmentioning

confidence: 99%

Effets de l’acéturate de diminazène et de l’hydrochlorure de mélarsamine sur les modifications des paramètres biochimiques chez des gazelles au front rouge (<em>Gazella rufifrons</em>) expérimentalement infectées avec <em>Trypanosoma brucei</em>

Mbaya

Aliyu

Nwosu

et al. 2008

Rev. Elev. Med. Vet. Pays Trop.

View full text Add to dashboard Cite

Une étude a été menée pour déterminer les effets chémothérapeutiques de l’hydrochlorure de mélarsamine (Cymelarsan®) et de l’acéturate de diminazène (Bérénil®) sur les paramètres biochimiques sanguins chez des gazelles au front rouge expérimentalement infectées par Trypanosoma brucei. Suite à la parasitémie des gazelles, les observations suivantes ont été faites : une augmentation significative (p < 0,05) de cortisol sérique, de l’alanine aminotransférase, de l’aspartate aminotransférase, de la bilirubine totale, de la créatinine, de l’urée, de l’acide urique et des lipides totaux, ainsi qu’une baisse significative des protéines sériques totales, du niveau de l’albumine et du glucose. En revanche, l’activité de la phosphatase d’alcaline a fluctué autour des valeurs normales (p > 0,05). Ces modifications biochimiques sont revenues à des valeurs proches de celles de la période de préinfection avant la fin de l’expérience chez les gazelles traitées avec 0,3 ou 0,6 mg/kg de poids vif (PV) de Cymelarsan ou 7,0 mg/kg de Bérénil. Les résultats semblent indiquer qu’un stress initial, associé à une augmentation du niveau du cortisol sérique et à son effet immunodépresseur pouvaient être responsable de l’installation et de l’expression clinique de l’infection chez les gazelles au front rouge. Par ailleurs, la sévérité des effets biochimiques produits expérimentalement a montré que la trypanotolérance chez les gazelles sauvages pouvait être compromise, surtout lorsque ces dernières étaient exposées au stress de la captivité. Les résultats ont aussi montré que le Cymelarsan à 0,3 ou 0,6 mg/kg PV et le Bérénil à 7,0 mg/kg PV étaient efficaces pour contrôler la maladie dans les conditions de l’expérience.

show abstract

Trypanosoma brucei gambiense: Changes in body temperature rhythms of infected New Zealand albino rabbits

Seed

Varney

1976

Experimental Parasitology

View full text Add to dashboard Cite

Biochemical studies in the vole, Microtus montanus—II. The effects of a Trypanosoma brucei gambiense infection on the diurnal variation of hepatic glucose-6-phosphatase and liver glycogen

Cited by 8 publications

References 19 publications

Mathematical analysis of circadian disruption and metabolic re-entrainment of hepatic gluconeogenesis: the intertwining entraining roles of light and feeding

Mathematical analysis of circadian disruption and metabolic re-entrainment of hepatic gluconeogenesis: the intertwining entraining roles of light and feeding

Effets de l’acéturate de diminazène et de l’hydrochlorure de mélarsamine sur les modifications des paramètres biochimiques chez des gazelles au front rouge (<em>Gazella rufifrons</em>) expérimentalement infectées avec <em>Trypanosoma brucei</em>

Trypanosoma brucei gambiense: Changes in body temperature rhythms of infected New Zealand albino rabbits

Contact Info

Product

Resources

About