“…Few books and book chapters provide a good overview of this topic. [153][154][155] Liquid-liquid partition of the water phase with polar organic solvents such as n-BuOH and sec-butanol or with mixtures such as CH x Cl y -MeOH 3 : 2 (CH 2 Cl 2 , CHCl 3 or CCl 4 ) can extract medium polar to polar compounds from the aqueous solution. A recent investigation on the capability of n-BuOH to extract organic analytes from aqueous solutions has been reported, including water-soluble compounds.…”
The isolation of water-soluble metabolites significantly diminished during the last decades. A comprehensive analysis on the isolation of hydrophilic natural products is discussed with a perspective for the future of natural product sciences.
“…Few books and book chapters provide a good overview of this topic. [153][154][155] Liquid-liquid partition of the water phase with polar organic solvents such as n-BuOH and sec-butanol or with mixtures such as CH x Cl y -MeOH 3 : 2 (CH 2 Cl 2 , CHCl 3 or CCl 4 ) can extract medium polar to polar compounds from the aqueous solution. A recent investigation on the capability of n-BuOH to extract organic analytes from aqueous solutions has been reported, including water-soluble compounds.…”
The isolation of water-soluble metabolites significantly diminished during the last decades. A comprehensive analysis on the isolation of hydrophilic natural products is discussed with a perspective for the future of natural product sciences.
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