Biochemical profile changes in stored donor blood for transfusion

Abstract

Objectives:This study’s aim was to find out that how various biochemical parameters of donor blood are affected during storage.Methods:This cross-sectional study was conducted in hematology Unit of Rehman Medical Institute, Peshawar and Fatimid Foundation, Peshawar Khyber Pakhtunkhwa, over a period of six months from June 2018 to November 2018. This study includes 300 healthy volunteer donors. Analysis of stored blood was done at 0, 3, 7, 14- and 21-days interval. Data were recorded and analyzed in SPSS v 20. A p value of less than 0.05 was taken as significant.Results:Three hundred healthy volunteer donors were included in the study in which 63% were male and 37% were females. Mean age was 26.54±7.3 years with age range from 23-46 years. Out of 300 donors 15.33% were O+, 35.33%, 9.66% B+, 8.33% A+, 7.66% AB+, 7.66% O-, 7% A- and 9% B-. Significant. Changes were observed in serum potassium, LDH, pH, serum chloride, serum sodium and AST levels. (p:<0.001). however, storage did not affect rest of the parameters.Conclusion:This study reveals that during storage certain changes occur in haematological and biochemical parameters which ultimately may put patients at risk.

Effect of Leukoreduction on Hematobiochemical Parameters and Storage Hemolysis in Canine Whole Blood Units

“…According to our results, in all LRWB and nLRWB units, we found significant progressively increased LDH levels, with strongly lower values in LRWB bags. These changes are comparable to those found in human blood units [7,69,70], suggesting that LDH could be an index of reliable hemolysis also in canine blood bags. In our study, the increase was significantly higher in the nLRWB units compared to the LRWB groups according to what happens in human medicine [69].…”

"Blood Donation – Medical Benefits for Blood Donors, Regarding the Management of Metabolic Parameters"

“…The deviations were noticed in donor's files (paper and electronic support), the donors were contacted by phone, and invited to return for the second check of significantly altered parameters, for medical interview, life and diet style assessment/ counseling, and where was necessary, guidance toward the general practitioners, or other specialists, such as, metabolic diseases specialists [4,5]. The evaluation was done and traced individually, till medical clarification, with subsequent reevaluation of blood donation admitting criteria.…”