Biochemical, Phytochemical Profile and Angiotensin-1 Converting Enzyme Inhibitory Activity of the Hydro-methanolic Extracts of Tulbaghia acutiloba Harv.

Arhin, Isaiah; Dwarka, Depika; Bissessur, Ajay; Naicker, Delon; Mackraj, Irene

doi:10.18311/jnr/2019/23485

Cited by 4 publications

(1 citation statement)

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“…Duncan et al, 23 found that aqueous and ethanolic extracts of leaves and roots of H. colchicifolia tested for ACE inhibition produced poor inhibition of between 4-37% inhibitions, with both leaf extracts having a greater inhibition than that of root extracts. Arhin et al, 24 showed a greater ACE inhibitory potential of the methanolic extracts of the leaves of Tulbaghia acutiloba with inhibition activity of 76.66 ± 1.65 (IC 50 154.23 μg/mL).…”

Section: Ace Inhibitionmentioning

confidence: 98%

In Vitro Anti-cancer, Anti-hypertensive and Antihyperglycaemic effect of Hypoxis colchicifolia

Moodley

Dwarka

Baijnath

et al. 2021

JNR

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Economic challenges associated with non-communicable diseases and the sociocultural outlook of many patients especially in Africa has increased the dependence on traditional herbal medicines for these diseases. Hypoxis colchicifolia is a traditional medicinal plant used in Southern Africa against an array of ailments. This study evaluated the in vitro antidiabetic (α-amyalse and α-glucosidase), antihypertensive (angiotensin-converting enzyme) and anticancer potential of H. colchicifolia corm as well as leaf (acetone, methanol and aqueous) extracts. Results showed that extracts have a moderate anti-diabetic and anti-hypertensive potential, with great anti-cancer potential. The acetone extract of both fresh and dried corms produced significant α-amylase and α-glucosidase inhibition with ACE inhibited predominantly by the dried corms methanolic extract (IC50 368.2 μg/mL). Methanolic extract of dried leaves showed the least cytotoxicity against the noncancerous cell line HEK-293 while exhibiting the highest inhibition of MCF-7 cells (IC50 3.24 μg/mL). All extracts exhibited a greater inhibitory potential in A549 cells than the positive control camptothecin (IC50 304.2μg/mL). This study reveals that H. colchicifolia has therapeutic potential as an anti-diabetic and anticancer agent; however, further in vivo studies need to be conducted.

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Section: Ace Inhibitionmentioning

confidence: 98%