BIOCHEMICAL PARAMETERS OF KIDNEY FUNCTION IN DONORS UNDER THE PRESENCE OF ANTI-SARS-CoV-2 IgG IN BLOOD

Abstract

Pandemic caused by SARS-CoV-2 virus in the world influences negatively on economic and social life, health care system. Conctracted COVID-19 patients suffered from outcome this disease after recovery because of SARS-CoV-2 has affected system disorder of body. Problems of digestion, blood coagulation, humoral and nervous systems could be discovered background disorder of respiratory system working. Besides, the clinical researches agree the changes of functioning kidneys in hospitalized patients suffered by SARS-CoV-2 virus. Therefore the pathological status of kidneys could develop in post-COVID-19 period. Our research is aimed to analysis of changes of concentration albumin, creatinine, urea and urea acid in blood plasma of donors with different titers of anti-SARS-CoV-2 IgG. Groups of donors were selected, in which the maximum and minimum values of the studied parameters were observed relative to the control group - donors without anti-SARS-CoV-2 IgG in blood. We determined that donor group with minimum titer of anti-SARS-CoV-2 IgG – 10 ± 3 Index (S/C) – have been characterized the maximum concentration of creatinine, urea and urea acid. Moreover the donor group with titer of anti-SARS-CoV-2 IgG 75 ± 5 Index (S/C) had the minimum concentration of albumin, creatinine, urea and urea acid. Obtained results could be linked with the potential influence of SARS-CoV-2 virus to kindey cells and consequents of immune response to infection caused by COVID-19 disease. Our research could be useful for treatment of COVID-19, which would involve the clinical therapy aimed not only at neutralizing the virus in the body, but also at reducing the negative load on the kidneys to prevent the development of pathological conditions in the post-COVID-19 period.