Biochemical Parameters of Clinical Significance in Rabbits

Fox, R. R.; Laird, Cleve W.; Blau, EM; Schultz, H. S.; Mitchell, BP

doi:10.1093/oxfordjournals.jhered.a108097

Cited by 17 publications

(4 citation statements)

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“…Values of glucose concentration in all groups of rabbits are higher than those found in rabbit serum (plasma) by Y u et al (1979), and as mentioned by S c heunert and Trautmann (1987) and Hewitt et al (1989). They are, however, very similar to the values found in rabbits by Fox and Laird (1970), Nordestgaard and Zilversmit (1988) and Lepitzki and Woolf (1991).…”

Section: Discussionsupporting

confidence: 91%

Protein and Fat Concentrations in the Blood Serum of Rabbits Fed Different Quantities of Dried Olive Cake

Rupić¹,

Skrlin²,

Mužic³

et al. 1999

Acta Vet. Brno

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The subject of this research is the nutritive effect that different quantities (10 and 20%) of dried olive cake had on total proteins and the proportion of individual proteins, on triacylglycerols, on total cholesterol, HDL and glucose in the serum of fattened rabbits following a 56-day experiment. The experiment involved 60 rabbits, divided into three groups: a control group (C) and two test groups (E 1 and E 2 ), each comprising 10 males and 10 females. Throughout the experiment, rabbits in group C received no olive cake in their feed; group E 1 rabbits were fed a feed mixture containing 10% of dried olive cake; group E 2 rabbits received a feed mixture containing 20% of dried olive cake. After the 56th day of the experiment, blood samples were obtained by cardiac puncture, and specific haematological variables, total proteins and their fractions, triglycerides, total cholesterol, HDL and glucose were established in the serum.The results obtained show no significant differences in the concentration of total proteins, albumin, alpha 1 , alpha 2 , beta and gamma globulin in the serum of rabbits in control group and in the two test groups. Similarly, no significant differences were found in the concentration of serum triacylglycerols and glucose between group C rabbits and the two test groups.However, group E 1 rabbits did show a significantly lower concentration of cholesterol compared with those in group E 2 ; group E 1 rabbits also had a significantly (P<0.01) lower concentration of HDL in their serum than those in group E 2 . Results of the study show that 10% and 20% of dried olive cake had neither detrimental effect on health, nor did they cause significant changes in the level of proteins, lipids and glucose in the serum of rabbits after a 56-day feeding period. Addition of dried olive cake into rabbit diets may therefore be recommended. Hyla rabbits, feeding, olive cake, serum, proteins, lipids and glucoseCultivation of olives has a long-standing tradition in many countries throughout the world, but it is particularly well developed in the Mediterranean area. Olive cake is the industrial by-product left following the extraction of oil from olives. The resulting considerable quantities of olive cake can be used as food for certain categories of livestock. Alternatively, they are simply deposited in the area around oil extraction plants where, due to their long period of degradation, they pollute the environment for prolonged periods of time. For certain types of animals (ruminants, rabbits, etc.) olive cake can be used as feed in somewhat greater quantities, while for chickens and pigs olive cake should form only a smaller portion of their daily diet. Depending on the technological procedure used in the extraction of olive oil, the resulting olive cake contains 3.5 -8.5% of oil, 2.5 -6.0% of raw proteins and other nutrients (Manoukas et al.; 1973, Rupiç et al.;1993, 1994.

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Section: Discussionsupporting

confidence: 91%

Protein and Fat Concentrations in the Blood Serum of Rabbits Fed Different Quantities of Dried Olive Cake

Rupić¹,

Skrlin²,

Mužic³

et al. 1999

Acta Vet. Brno

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“…2). Diurnal fluctuations in hematological measurements, including plasma iron and TIBC, also have been reported in rabbits and humans and attributed to the release of iron from the reticuloendothelial system (10,28,29,61), although more recent evidence demonstrates that hepcidin, an iron-regulatory hormone released from hepatocytes, also regulates iron flux into the blood. During times of inflamma-tion or elevated body iron, hepcidin complexes with the iron exporter ferroportin causing ferroportin to be internalized and degraded, thus preventing release of more iron into the body from both gastrointestinal absorptive cells and macrophages (44,49,63).…”

Section: Discussionmentioning

confidence: 93%

Diurnal cycle influences peripheral and brain iron levels in mice

Unger¹,

Earley²,

Beard³

2009

Journal of Applied Physiology

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Iron movement between organ pools involves a dynamic equilibrium of iron efflux and uptake, and homeostatic mechanisms are likely involved in providing iron to cells and organs when required. Daily iron levels in the plasma pool fluctuate with the diurnal cycle, but clear explanations regarding the objectives and regulation of the flux are lacking. The association between diurnal cycle and iron flux is relevant in the disease of restless legs syndrome (RLS), where individuals display diurnal deficits in motor control, have impaired brain iron metabolism, and perhaps altered iron uptake from the plasma pool. The goal of the present study was to examine diurnal variations in peripheral and regional brain iron to evaluate iron flux between organs in iron-sufficient and iron-deficient mice. In mice fed control diet, liver iron was elevated 30-40%, and plasma iron was reduced 20-30% in the active dark period compared with the inactive light phase. Dietary iron deficiency eliminated this variation in liver iron in male and female mice and in plasma iron in male mice. Reductions in ventral midbrain and nucleus accumbens iron and ferritin were apparent in iron-deficient mice during both diurnal phases, but only during the light phase was an approximately 25% reduction in whole brain iron observed, suggesting different brain iron requirements between phases. These data demonstrate that iron flux between organs is sensitive to diurnal regulatory biology. Importantly, variations in brain iron may have temporal implications regarding neural functioning and may contribute to the diurnal cycle-dependent symptoms of RLS.

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“…Exactly why we failed to replicate their Hct QTL is unknown at this time. One factor may have been time of day of collection, as Hct is known to show a circadian rhythm in rabbits and rats and (24,54) and probably in mice as well. In our work, we routinely kill and harvest between the hours of 0900 and 1200, i.e., 3-6 h after lights are turned on in the vivarium.…”

Section: Discussionmentioning

confidence: 99%

Systems genetic analysis of peripheral iron parameters in the mouse

Jones¹,

Beard²,

Gibson³

et al. 2007

American Journal of Physiology-Regulatory, Integrative and Comp

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Iron homeostasis is one of the most critical functions in living systems. Too little iron can lead to anemia and tissue-specific disorders, such as splenomegaly. Excessive systemic iron is characteristic of hemochromatosis and is implicated in the brain in Parkinson's disease. With the exception of some single gene diseases like hemochromatosis, we know little about genetic-based, individual differences in iron-related parameters and their impact on biology. To model genetic control of iron homeostasis, we measured liver, spleen, and plasma iron concentrations, hematocrit and hemoglobin, transferrin saturation, and total iron-binding capacity in several BXD/Ty recombinant inbred mouse strains derived from C57BL/6 and DBA/2 progenitors. At 120 days of age, the animals were killed for iron analysis. All measures showed genetic-based variability consistent with polygenic influence. Analysis of principal components of the seven measures revealed three factors that we named availability, transport, and storage. Quantitative trait loci (QTL) analysis revealed one suggestive QTL on chromosome 5 for availability, two suggestive QTL (one on chromosome 1 and the other on chromosome 7) for transport, and one weak QTL on chromosome 2 for storage. The results show that iron homeostasis is a complex trait and is influenced by multiple genes.

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Biochemical Parameters of Clinical Significance in Rabbits

Cited by 17 publications

References 0 publications

Protein and Fat Concentrations in the Blood Serum of Rabbits Fed Different Quantities of Dried Olive Cake

Protein and Fat Concentrations in the Blood Serum of Rabbits Fed Different Quantities of Dried Olive Cake

Diurnal cycle influences peripheral and brain iron levels in mice

Systems genetic analysis of peripheral iron parameters in the mouse

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