Biochemical parameters of blood serum in rats during therapy of thermal injury in the water environment

Кузнецов, В. И.; Kuznecov, V.; Соловьева, А. С.; Перетягин, С. П.; Peretyagin, S. P.; Kostina, O. V.; Костина, О. Я.; Преснякова, М В; Presnyakova, M.V.; Перетягин, П. В.; Peretyagin, P. V.; Luzan, A. S.

doi:10.12737/article_59c4a5664962b7.12610607

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“…Наблюдалось умеренное увеличение уровня ферментов АСТ, АЛТ и щелочной фосфатазы, что, вероятно, связано с интоксикацией печени продуктами распада ожоговой раны. Также повышение содержания АЛТ в крови может быть индуцировано за счет повышения уровня аланина в крови -постоянного спутника ожоговой травмы [12]. Расстройство гемодинамики и кислотно-щелочного баланса, нарушение функции почек и желудочно-кишечного тракта характерны для ожогового шока, который развивается при ожогах общей площадью более 15 % поверхности тела или глубоких ожогах более 10 % поверхности тела [13].…”

Section: результаты и обсуждениеunclassified

Thermal skin burn in a late gestation period in experimental animals: state of the system “mother-fetus”

Kovalchuk-Bolbatun

Smotryn

2021

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Objective. To study the effect of thermal skin burns in experimental animals (rats) on the state of the system “mother-fetus” in a late gestation period.Materials and methods. An experimental study was carried out on 18 female outbred white rats weighing 300–350 g (per 9 rats in the control and experimental groups), which were exposed to third-degree thermal burns with an area of 12 cм2 in a late gestation period. The oxygen transport function and the main blood biochemical markers were studied. The effect of thermal injury on the course of pregnancy was studied.Results. The thermal skin burn in the rats in the late gestation period leads to the development of hypoxia, a decrease in the affinity of hemoglobin for oxygen and metabolic acidosis in the mother’s body. Changes in the blood biochemical markers indicate the presence of endogenous intoxication. In the experimental animal group, a decrease in fetal weight was observed, an increase in the post-implantation fetal death rate was noted.Conclusion. Impaired oxygen homeostasis and endogenous intoxication in skin burns in rats in late gestation periods lead to fetal malnutrition and a qualitative increase in the post-implantation fetal death rate.

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Section: результаты и обсуждениеunclassified

Thermal skin burn in a late gestation period in experimental animals: state of the system “mother-fetus”

Kovalchuk-Bolbatun

Smotryn

2021

jour

View full text Add to dashboard Cite

show abstract

Biochemical parameters of blood serum in rats during therapy of thermal injury in the water environment

Cited by 1 publication

References 0 publications

Thermal skin burn in a late gestation period in experimental animals: state of the system “mother-fetus”

Thermal skin burn in a late gestation period in experimental animals: state of the system “mother-fetus”

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