Biochemical Parameters correlated with Tumour Cell Implantation

Differences in behavior and prognosis between leukemic and lymphomatous forms of a transplantable hamster lymphocytic neoplasm induced by simian virus 40.

“…The behavior and prognosis, therefore, of the two forms of this SV40-induced transplantable lymphocytic neoplasm parallel the behavior and prognosis of the analogous lymphocytic malignant neoplasms developing spontaneously in humans. As a result, this animal model as well as others similarly derived, can serve as a means to elucidate the factors (25)(26)(27) responsible for the differences in behavior noted between the leukemic and lymphomatous forms of a lymphocytic neoplasm. They can also assist in evaluating the efficacy of different modes of therapy, the effect of which may vary in the two forms of the neoplastic process.…”

A correlation between cancer metastases and the fluidity of cancer cell membrane.

“…Furthermore, Fidler (1973b) succeeded in obtaining the metastatic strains of B16 melanoma by means of intravenous injection and tissue culture of the metastatic lesions. Bosmann et al (1973) studied the biochemical features of these "super metastatic strains" and demonstrated changes in the electrophoretic mobility, increased degradative enzymes, surface glycoproteins and proteases. Nakazawa et al (1978) studied lipid-chemical features of metastatic lesions of human cancer and recognized a marked change in the phospholipid fatty acid composition of the metastatic lesions in the liver as compared with that of primary lesions; percentages of the fatty acids which promote membrane lipid fluidity were increased…”

Some features of the metastatic cancer cells in prostaglandin production.

“…Fidler (1973b) succeeded also in obtaining the highly metastatic strains of B16 melanoma by means of intravenous injection and tissue culture of the metastatic lesions. Bosmann et al (1973) recognized the biochemical features of the most highly metastatic strain (F10), that is, the change in the electrophoretic mobility, surface glycoprotein, proteases and increasing degradative enzyme as compared with those of low metastatic B16 melanoma …”

“…Tohoku J. Exp. Med., 1989, 159 (1), [75][76][77][78] In order to establish metastatic lesions, 2.5>< 106 AH100B cells were injected into the left carotid artery of male Donryu rats. Each metastatic nodule in the liver or kidney, 1 mm or less in diameter, thus obtained was then injected into the peritoneal cavity in which these metastatic cells come to free.…”