Biochemical Parameters as Prognostic Factors in Prostatic Adenocarcinoma

Vesalainen, S; Lipponen, P; Talja, Martti; Syrjänen, Karí

doi:10.3109/02841869509093639

Cited by 10 publications

(6 citation statements)

References 15 publications

(4 reference statements)

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“…The significantly augmented levels of creatinine in the filtered-serum of PC compared with BPH and HC ( Fig. 3) concur with the previous observation where serum creatinine levels were correlated to the Gleason score of PC [30] and to measures of PC risk in a prospective study [31]. Creatine is a precursor of creatinine ( Fig.…”

Section: Discussionsupporting

confidence: 90%

NMR spectroscopy of filtered serum of prostate cancer: A new frontier in metabolomics

et al. 2016

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(1) H NMR-based metabolic profiling of filtered-serum sample appears to be assuring, swift, and least-invasive for probing and prediction of PC and BPH with its signature metabolic profile. This novel technique is not only on a par with histopathological evaluation of PC determination but is also comparable to liquid chromatography-based mass spectrometry to identify the metabolites. Prostate 76:1106-1119, 2016. © 2016 Wiley Periodicals, Inc.

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Section: Discussionsupporting

confidence: 90%

NMR spectroscopy of filtered serum of prostate cancer: A new frontier in metabolomics

et al. 2016

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“…These CBC criteria was associated with relatively no effects on liver and kidney functions (P>0.05). This observation was supported by the work of Chiong and Ribeiro which revealed that creatinine concentrations predicted advanced prostate carcinoma and decreased survival in one study (Vesalainen et al, 1995) and were elevated in patients presenting with high PSA and locally advanced or metastatic disease (Chiong et. al., 2005 andRibeiro et.…”

Section: Discussionsupporting

confidence: 53%

Hematological and Biochemical Studies of Prostate Cancer in Hospitals of Zagazig University

Salama

2022

Bulletin of Faculty of Science, Zagazig University

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Prostate cancer is considered as the most commonly diagnosed cancer cause of death among men, reports in 2020 estimated that about 191, 930 were new cases with 33,330 expected to die of this disease. This elevating rate making it the second most commonly diagnosed cancer type in men. Early prognosis of prostate cancer can give hope for early recovery. But in clinical oncology units, diagnosis may be associated with different not specific physiological and biochemical measurements to make a decision. The aim of this study is to investigate the possible association progression of prostate cancer and the underlying metabolic and physiological changes in blood samples among Egyptian males at Zagazig University Hospitals. Fifty prostatic cancer patients treated and followed-up at clinical oncology & nuclear medicine department. Biochemical parameters including albumin, urea, creatinine were measured in blood. Results showed a statistically significant decrease of hemoglobin and RBCs count of prostate cancer cases compared to their controls (P=0.001 and 0.005) respectively, while other CBC parameters were statistically not significant between both groups (P>0.05). Other liver and kidney function tests showed no significant difference between the two studied groups (P>0.05). on the other hand, we found a significant increase in levels of ALT and AST enzymes in blood of prostate cancer patient compared with control while the levels of albumin showing no difference between patient and control. Finally, reading revealed no significant differences in the levels levels of creatinine and urea between patient and control participants. These observations declared that levels of albumin, creatinine and urea in blood could be ignored in prognosis of prostate cancer.

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“…For example, creatinine concentrations predicted advanced prostate carcinoma and decreased survival in one study (3) and were elevated in patients presenting with high PSA and locally advanced or metastatic disease, compared with those with low initial PSA (2). Elevated serum creatinine was also associated with reduced survival in a group of men with hormone-resistant prostate cancer (4).…”

Section: Discussionmentioning

confidence: 99%

“…The only established risk factors for this malignancy are age, family history, race, and some common genetic variants. Studies among prostate cancer patients have shown that serum creatinine is associated with more advanced disease (2,3) and with decreased survival (3,4), although this relationship is not supported by some studies (5–8). Serum creatinine could be a marker for homocysteine status and one carbon metabolism, as synthesis of the fomer results in removal of a methyl group from S-adenosylmethionine, creation of homocysteine, and potentially reducing availability of one-carbon groups for DNA methylation, synthesis, and repair (9,10).…”

Section: Introductionmentioning

confidence: 95%

Serum Creatinine and Prostate Cancer Risk in a Prospective Study

Weinstein

Mackrain

Selhub

et al. 2009

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Several studies have examined serum creatinine as a marker for prostate cancer stage, recurrence, and prognosis. We evaluated whether serum creatinine concentration was associated with risk of developing prostate cancer in a prospective cohort of male smokers. Methods: A nested case-control study within the AlphaTocopherol, Beta-Carotene Cancer Prevention Study of 50-to 69-year-old Finnish men was conducted. Two controls (n = 464) were matched to each case (n = 232) on study center, intervention group, date of baseline blood draw (±45 days), and age (±5 years). Conditional logistic regression was used to calculate odds ratios and 95% confidence intervals. All P values were two-sided. Results: Cases had significantly higher prediagnostic serum creatinine concentrations compared with controls (medians of 1.13 versus 1.10 mg/dL, respectively; P =

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Biochemical Parameters as Prognostic Factors in Prostatic Adenocarcinoma

Cited by 10 publications

References 15 publications

NMR spectroscopy of filtered serum of prostate cancer: A new frontier in metabolomics

NMR spectroscopy of filtered serum of prostate cancer: A new frontier in metabolomics

Hematological and Biochemical Studies of Prostate Cancer in Hospitals of Zagazig University

Serum Creatinine and Prostate Cancer Risk in a Prospective Study

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