Biochemical Mechanisms of Tumor Invasion and Metastases

Liotta, Lance A.; Wewer, Ulla M.; Rao, N C; Schiffmann, Elliott; Stracke, Mary L.; Guirguis, Raouf; Thorgeirsson, Unnur P.; Muschel, Ruth J.; Sobel, Mark E.

doi:10.1007/978-1-4899-5037-6_18

Cited by 69 publications

(50 citation statements)

References 16 publications

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“…The invasion is particularly complicated process and key step in the cancer metastatic cascade (Liotta et al 1988). During the past 20 years, primary liver cancer, 95% of which is hepatocellular carcinoma, has ranked third in men and fifth in women as a cause of death from malignant neoplasm in Japan (Kiyosawa et al 2004).…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effect of gingerol on the proliferation and invasion of hepatoma cells in culture

2008

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Section: Introductionmentioning

confidence: 99%

Inhibitory effect of gingerol on the proliferation and invasion of hepatoma cells in culture

2008

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“…Proteases have long been recognized to play an important role in cell migration and tissue remodeling in various pathological conditions, especially tumor cell invasion and metastasis (Liotta, 1987;Liotta et al, 1988;Ossowski, 1988a,b;Werb, 1989Werb, , 1997Alexander and Werb, 1991;Monsky and Chen, 1993;StetlerStevenson et al, 1993). Because morphogenetic movements and tissue remodeling are prominent developmental processes, it is likely that proteases have a significant role in embryogenesis as well (Werb, 1997).…”

Section: Introductionmentioning

confidence: 99%

MMP‐2 plays an essential role in producing epithelial‐mesenchymal transformations in the avian embryo

Duong

Erickson

2003

Developmental Dynamics

129

103

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To investigate the roles that matrix-degrading proteases may have in development of the chicken embryo, we documented the expression pattern of matrix metalloprotease-2 (MMP-2, 72-kDa type IV collagenase or gelatinase A) and perturbed its function in vitro and in vivo. MMP-2 is expressed as neural crest cells detach from the neural epithelium during an epithelial-mesenchymal transformation (EMT) but is rapidly extinguished as they disperse. It is also expressed in the sclerotome and in the dermis at the time that the EMT is initiated, and also as these cells migrate, and is down-regulated once motility has ceased. These patterns suggest that MMP-2 plays a role in cell motility during the EMT and during later morphogenesis.

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“…This result suggests that anti-b-galactosyl antibody recognize some antigen(s) on AH109A cells rather than on M-cells. The attachment of tumor cells to normal cell layer is known to be the first step for the invasion (Liotta et al 1988). We finally investigated the effect of anti-bgalactosyl antibody on the adhesion of AH109A cells to M-cell monolayer (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Invasion is the most important and characteristic event in tumor metastasis (Liotta et al 1988). Metastasis is a complex and sequential cascade of events that leads to the dissemination of tumor cells to distant tissues.…”

Section: Introductionmentioning

confidence: 99%

Natural IgG antibody with anti-β-galactosyl specificity suppressed hepatoma cell invasion in culture

et al. 2012

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The effect of natural IgG antibody recognizing b-galactosyl epitope on hepatoma cell invasion was investigated. Anti-b-galactosyl antibody dosedependently suppressed hepatoma invasion underneath primarily cultured mesothelial cells monolayer without affecting the proliferation, to the same extent as natural IgG antibody with anti-a-galactosyl specificity, which had already been reported to have an anti-metastatic activity. The inhibitory effect of anti-b-galactosyl antibody was completely canceled by adding lactose (galactose-b-1, 4-glucose) to the medium, indicating that this antibody recognized some antigens with bgalactosyl epitope. Hepatoma cells pretreated with this antibody for 48 h showed reduced invasive activity, while the pretreatment of mesothelial cells with the antibody did not affect hepatoma cells invasion. Anti-bgalactosyl antibody also suppressed hepatoma cells adhesion to mesothelial cells monolayer. These results suggest that natural antibody with anti-b-galactosyl specificity may recognize the b-galactosyl epitope in some adhesion-related molecules on hepatoma cells, thus suppressing adhesion and invasion to mesothelial cells monolayer. These results suggest possible therapeutic uses of this antibody in the treatment of metastatic tumors.

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Biochemical Mechanisms of Tumor Invasion and Metastases

Cited by 69 publications

References 16 publications

Inhibitory effect of gingerol on the proliferation and invasion of hepatoma cells in culture

Inhibitory effect of gingerol on the proliferation and invasion of hepatoma cells in culture

MMP‐2 plays an essential role in producing epithelial‐mesenchymal transformations in the avian embryo

Natural IgG antibody with anti-β-galactosyl specificity suppressed hepatoma cell invasion in culture

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