Biochemical mechanism of the antimalarial activity ofAzadirachta indica leaf extract

Iwu, Maurice M.; Obidoa, Onyechi; Anazodo, M. I.

doi:10.1016/0031-6989(86)90161-x

Cited by 37 publications

(24 citation statements)

References 11 publications

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“…It has been suggested that the increase of oxidative stress by flavonoids and triterpenes on the parasites could result in peroxidation of membrane lipids (Iwu et al, 1986) and inhibition of transport of nucleotides essential for the development of the parasite (Takahira et al, 1998).…”

Section: Resultsmentioning

confidence: 99%

Evaluation of clastogenic potential of the antimalarial plant Solanum nudum

Álvarez

Pabón

Carmona

et al. 2004

Phytotherapy Research

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Compounds isolated from Solanum nudum have shown in vitro antimalarial activity against the FCB-2 strain of Plasmodium falciparum. Diosgenone (C27H40O3) the main component isolated from the hexane extract and an aqueous extract were evaluated to measure their clastogenic potential using the micronucleus test. Three concentrations (16, 32 and 64 g/kg of weight) of the aqueous extract were administered intraperitoneally into mice, (the highest concentration corresponded to 80% LD50) and diosgenone solubilized in olive oil was inoculated at the highest concentration possible (11.187 g/kg of weight). After administration of the compounds, no induction of micronucleus was observed either in polychromatic or normochromatic erythrocytes. Interestingly, a reduction of 51% in the young/mature erythrocytes ratio was seen in cells treated with aqueous extract. We conclude that neither diosgenone nor the aqueous extract have clastogenic activity, and that the aqueous extract showed some toxicity at the above mentioned concentrations. These results are significant since diosgenone could be a new therapeutic alternative for the treatment of malaria.

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Section: Resultsmentioning

confidence: 99%

Evaluation of clastogenic potential of the antimalarial plant Solanum nudum

Álvarez

Pabón

Carmona

et al. 2004

Phytotherapy Research

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“…At high doses (100 mg/kg) in rats, paracetamol produced significant lipid peroxidation in hepatic and renal tissues, with concomitant depletion of glutathione (Essien, 1991). Azadirachta indica (Meliaceae) another plant commonly used as antimalarial significantly reduced body weight, total plasma protein levels (Ibrahim et al, 1992) and increased the generation of methaemoglobin in rats (Iwu et al, 1986). Garlic (Allium sativum L.) has antihyperglycaemic and hypolipidemic activities in nicotine-induced hyperglycaemia and hyperlipidemia in rats (Sheriff and Effraim, 1998).…”

Section: Introductionmentioning

confidence: 98%

Effects of Khaya grandifoliola (Meliaceae) on some biochemical parameters in rats

Bumah

Essien

Agbedahunsi

et al. 2005

Journal of Ethnopharmacology

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“…Clinical studies have shown the drug to be a safe and effective antimalarial agent even in the cases of chloroquineresistant P. falciparum malaria (Quinghasu Antimalaria Coordinating Research Group, 1979), and especially those of cerebral malaria (China Cooperative Research Group on Qinghaosu, 1982;Klayman, 1985). Isolation of artemisinin and the development of more effective derivatives from this drug (Van Agtmael et al, 1999) have led to further trials for identifying other medicinal compounds as potential antimalarial agents from natural products (Iwu et al, 1986;Isaka et al, 1999).…”

Section: Introductionmentioning

confidence: 98%

Comparison of antimalarial activity of the alkaloidal fraction of Hydrangea macrophylla var. Otaksa leaves with the hot‐water extract in ICR mice infected with Plasmodium yoelii 17 XL

Ishih

Miyase

Terada

2003

Phytotherapy Research

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The antimalarial activity of the fractions isolated from the leaves of Hydrangea macrophylla Seringe var. Otaksa Makino was evaluated against Plasmodium yoelii 17 XL in mice. Four different fractions were prepared in the usual manner to obtain an alkaloid fraction. All mice treated with the fraction containing febrifugine and isofebrifugine mixture at 1 mg/kg twice a day for 5 consecutive days survived during the experiment, and the change of mean parasitemia level showed almost the same pattern as that from mice treated with the hot-water extract of the same plant leaves. Activity of this fraction, however, was markedly reduced compared with the hot-water extract. Furthermore, no antimalarial activity was shown in the hotwater extract from H. macrophylla var. Otaksa roots or Dichroa febrifuga Lour. leaves.

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Biochemical mechanism of the antimalarial activity ofAzadirachta indica leaf extract

Cited by 37 publications

References 11 publications

Evaluation of clastogenic potential of the antimalarial plant Solanum nudum

Evaluation of clastogenic potential of the antimalarial plant Solanum nudum

Effects of Khaya grandifoliola (Meliaceae) on some biochemical parameters in rats

Comparison of antimalarial activity of the alkaloidal fraction of Hydrangea macrophylla var. Otaksa leaves with the hot‐water extract in ICR mice infected with Plasmodium yoelii 17 XL

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