Biochemical Markers of Bone Turnover

Biochemical markers of bone collagen type I metabolism

“…In particular, bone isoenzyme is thermolabile and B-ALP activity is completely inhibited in response to heat at 56 ºC for 10 min. Residual activity becomes below 20% of initial activity after heating serum sample that represents partial bone isoenzyme activity [4,5].…”

“…Additional difficulties are caused by the blood circulating calcium-binding TRAP form. That is why it should be separated before measurement [4,5,8].…”