Biochemical markers of bone turnover

Swaminathan, R.

doi:10.1016/s0009-8981(01)00656-8

Cited by 149 publications

(135 citation statements)

References 42 publications

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“…Serum total alkaline phosphatase (TALP) and bone alkaline phosphatase (BALP) were determined colorimetrically according to the method described by Belfield and Goldberg (1971). TALP and BALP were estimated on the day of collection as ALP has a half-life of 1 to 2 days (Swaminathan, 2001). Parathyroid hormone (PTH) was estimated using IRMA PTH kit (A11930, Beckman Coulter Company) and calcitonin was determined by DRG ELISA kit according to Tiegs et al (1986).…”

Section: Biochemical Analysesmentioning

confidence: 99%

Antiosteoporotic effect of Coelatura aegyptiaca shell powder on ovariectomized rats

Sayed¹,

Soliman²,

Fahmy³

et al. 2013

Afr. J. Pharm. Pharmacol.

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The efficacy of Coelatura aegyptiaca shell powder (CES, 500 mg/kg BW) was evaluated as a calcium supplement in ovariectomized (OVX) rats for ten weeks of treatment. The biochemical components and the antioxidant properties of the shell powder were determined. The bone mineral density (BMD), bone mineral content (BMC), calcium (Ca) and phosphorus (P) contents in serum and bone, serum total alkaline phosphatase (TALP) and bone alkaline phosphatase (BALP), serum calcitonin and parathyroid (PTH) hormones were determined. Furthermore, some of the oxidative stress markers [malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx) and total antioxidant capacity (TAC)] were estimated in bone. The current study revealed that CES contained 19.38% Ca, 0.315% P as well as some of antioxidant amino acids which have a potent antioxidant activity against 1,1-diphenylpicrylhydrazyl (DPPH) free radical. Administration of CES to OVX rats increased BMD, BMC, tibial Ca and P contents and BALP activity, as compared to OVX rats. An ameliorative effect was recorded in the levels of calcitonin, PTH, MDA, SOD, GPx and TAC subsequent to CES administration to OVX rats.This ameliorative effect of CES powder against osteoporosis may be attributed to its antioxidant efficacy and/or to its Ca content. In conclusion, CES may have the potential to develop a clinically useful anti-osteoporotic agent, since its effect was comparable with alendronate (6.5 mg/kg BW/week).

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Section: Biochemical Analysesmentioning

confidence: 99%

Antiosteoporotic effect of Coelatura aegyptiaca shell powder on ovariectomized rats

Sayed¹,

Soliman²,

Fahmy³

et al. 2013

Afr. J. Pharm. Pharmacol.

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show abstract

“…Kemiğin bu aktif durumunu yakından izleyebilmek için, yapım ve yıkım sırasında ortaya çıkan birtakım protein kaynaklı ürünlerin ve enzim ölçümlerinden faydalanır ve bunların tümüne kemiğin biyokimyasal markırları denir 19 . Kemik metabolizmasının biyokimyasal markırları, osteoblast ve osteoklastlardan salınan maddeler ile kemiğe özgü kollagen yıkım ürünleridir 20,21 . Bu biyokimyasal markırlar, kemik yapımının ve yıkımının izlenmesinde kullanılmaktadır 22 .…”

Section: Discussionunclassified

Relationship Between Ageing and Bone Turnover Markers in Periodontal Disease

Kursunlu¹,

Öztürk²

2013

BSBD

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“…Biochemical markers for assessing bone turnover, which can be used to diagnose metabolic bone diseases, have been developed and made commercially available during the last few decades (Seibel 2000;Swaminathan 2001). Bone resorption markers comprised of urinary type I collagen degradation products, such as free or total pyridinium cross-linked pyridinoline or deoxypyridinoline and cross-linked N-terminal telopeptides (NTX) and C-terminal telopeptides (CTX), are most widely used.…”

confidence: 99%

Higher Efficacy of Urinary Bone Resorption Marker Measurements in Assessing Response to Treatment for Osteoporosis in Postmenopausal Women

Abe

Ishikawa

Fukao

2008

Tohoku J. Exp. Med.

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Osteoporosis has reached epidemic proportions. This situation has stimulated the development of biochemical markers to assist in assessing osteoporotic risk and monitoring treatment effi cacy. Biochemical markers for assessing the level of bone resorption have been developed during the last few decades. One of the most widely used bone resorption markers is cross-linked N-terminal telopeptides (NTX). Measurements of urinary and serum NTX provide indications of the level of bone resorption during osteoporosis treatment. However, it remains unclear whether urinary or serum NTX measurements show better effi cacy for assessing osteoporosis treatment effects during the early phase of treatment. Therefore, the primary aim of the present study was to compare the effi cacies of urinary and serum NTX measurements for assessing the level of bone resorption during the early stage of osteoporosis treatment. We enrolled 43 postmenopausal Japanese women in an open-label randomized placebo-controlled trial. Overall, 21 women in the osteoporosis treatment group and 19 women in the placebo group completed the study. There was a signifi cant reduction in urinary NTX in the treatment group, which was detectable as early as 4 weeks and maintained until 16 weeks, compared with the placebo group. On the other hand, serum NTX did not show a signifi cant reduction in the treatment group compared with the placebo group until 16 weeks. These results indicate that urinary NTX measurements are more sensitive and show higher effi cacy than serum NTX measurements for assessing treatment effect during the early phase of osteoporosis treatment in postmenopausal women.biomarker; NTX; osteoporosis; signal-to-noise ratio; postmenopausal women. Tohoku

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Biochemical markers of bone turnover

Cited by 149 publications

References 42 publications

Antiosteoporotic effect of Coelatura aegyptiaca shell powder on ovariectomized rats

Antiosteoporotic effect of Coelatura aegyptiaca shell powder on ovariectomized rats

Relationship Between Ageing and Bone Turnover Markers in Periodontal Disease

Higher Efficacy of Urinary Bone Resorption Marker Measurements in Assessing Response to Treatment for Osteoporosis in Postmenopausal Women

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