Biochemical markers (NSE, S-100, IL-8) as predictors of neurological outcome in patients after cardiac arrest and return of spontaneous circulation

Ekmektzoglou, Konstantinos; Xanthos, Theodoros; Papadimitriou, Lila

doi:10.1016/j.resuscitation.2007.03.016

Cited by 49 publications

(24 citation statements)

References 78 publications

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“…After these 29 papers were reviewed in full text and searched for cross-references, 31 papers were finally selected for the present review. The full-text contents of all 31 papers, which included 26 original articles [14-39] and five review articles [1,2,9,10,40], were reviewed and compared. Twenty-one original articles [14,18,21-39] investigated NSE, while 14 [14-20,22,25,26,28,29,31,39] investigated S-100B.…”

Section: Resultsmentioning

confidence: 99%

“…The design adopted varied from study to study, making a systematic literature review extremely difficult [10,40]. The major problems encountered during the review process involved variation or heterogeneity among studies in the following three respects: definitions of outcome to be assessed (e.g., some studies adopted grouping criteria for outcome different from others); the value of specificity corresponding to each cut-off value reported for a particular biochemical marker predictive of a poor prognosis (i.e., not always fixed at 100%); and specification of blood sampling time points (i.e., not always uniform application of a blood sampling schedule to all subjects with sampling intervals specified).…”

Section: Discussionmentioning

confidence: 99%

“…Although few reviews of application of biological markers to prediction of neurological outcome in CA after CPR published meet the above requirements [1,10], the present study is the first extensive literature review that does meet them.…”

Section: Introductionmentioning

confidence: 94%

“…Serum levels of protein neuron-specific enolase (NSE) and S-100B are considered promising candidates for neurological prognostic predictors in patients with ROSC after CPR, and many investigations on the clinical usefulness of these biochemical markers in predicting neurological outcomes after CPR have been published [1,9,10]. In the present study, we performed an extensive literature review to examine the clinical usefulness of NSE and S-100B as post-resuscitation neurological prognostic predictors.…”

Section: Introductionmentioning

confidence: 99%

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S-100B and neuron-specific enolase as predictors of neurological outcome in patients after cardiac arrest and return of spontaneous circulation: a systematic review

et al. 2009

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IntroductionNeurological prognostic factors after cardiopulmonary resuscitation (CPR) in patients with cardiac arrest (CA) as early and accurately as possible are urgently needed to determine therapeutic strategies after successful CPR. In particular, serum levels of protein neuron-specific enolase (NSE) and S-100B are considered promising candidates for neurological predictors, and many investigations on the clinical usefulness of these markers have been published. However, the design adopted varied from study to study, making a systematic literature review extremely difficult. The present review focuses on the following three respects for the study design: definitions of outcome, value of specificity and time points of blood sampling.MethodsA Medline search of literature published before August 2008 was performed using the following search terms: "NSE vs CA or CPR", "S100 vs CA or CPR". Publications examining the clinical usefulness of NSE or S-100B as a prognostic predictor in two outcome groups were reviewed. All publications met with inclusion criteria were classified into three groups with respect to the definitions of outcome; "dead or alive", "regained consciousness or remained comatose", and "return to independent daily life or not". The significance of differences between two outcome groups, cutoff values and predictive accuracy on each time points of blood sampling were investigated.ResultsA total of 54 papers were retrieved by the initial text search, and 24 were finally selected. In the three classified groups, most of the studies showed the significance of differences and concluded these biomarkers were useful for neurological predictor. However, in view of blood sampling points, the significance was not always detected. Nevertheless, only five studies involved uniform application of a blood sampling schedule with sampling intervals specified based on a set starting point. Specificity was not always set to 100%, therefore it is difficult to indiscriminately assess the cut-off values and its predictive accuracy of these biomarkers in this meta analysis.ConclusionsIn such circumstances, the findings of the present study should aid future investigators in examining the clinical usefulness of these markers and determination of cut-off values.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

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S-100B and neuron-specific enolase as predictors of neurological outcome in patients after cardiac arrest and return of spontaneous circulation: a systematic review

et al. 2009

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“…Therefore, angiography is often delayed until the neurological status of the patient can be determined accurately. Blood markers may help to estimate the impact of hypoxic brain injury, such as the levels of the protein “neurone specific enolase”, “S-100” or “IL-8”, although predictive value and accuracy varies widely in different studies [67, 68]. More precise tools to predict outcomes would help tremendously for optimal resource allocation [69].…”

Section: Prognosis After Scamentioning

confidence: 99%

Out-of-Hospital Cardiac Arrest –Optimal Management

Fröhlich¹,

Lyon²,

Sasson³

et al. 2014

CCR

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Out-of-hospital cardiac arrest (OHCA) has attracted increasing attention over the past years because outcomes have improved impressively lately. The changes for neurological intact outcomes has been poor but several areas have achieved improving survival rates after adjusting their cardiac arrest care. The pre-hospital management is certainly key and decides whether a cardiac arrest patient can be brought back into a spontaneous circulation. However, the whole chain of resuscitation including the in-hospital care have improved also. This review describes aetiologies of OHCA, risk and potential protective factors and recent advances in the pre-hospital and in-hospital management of these patients.

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Development of a prompt model for predicting neurological outcomes in patients with return of spontaneous circulation from out‐of‐hospital cardiac arrest

Kumagai

Oda

Oshima

et al. 2014

Acute Medicine & Surgery

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Aim: Early prediction of the neurological outcomes of patients with out-of-hospital cardiac arrest is important to select the optimal clinical management. We hypothesized that clinical data recorded at the site of cardiopulmonary resuscitation would be clinically useful.Methods: This retrospective cohort study included patients with return of spontaneous circulation after cardiopulmonary resuscitation who were

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Biochemical markers (NSE, S-100, IL-8) as predictors of neurological outcome in patients after cardiac arrest and return of spontaneous circulation

Cited by 49 publications

References 78 publications

S-100B and neuron-specific enolase as predictors of neurological outcome in patients after cardiac arrest and return of spontaneous circulation: a systematic review

S-100B and neuron-specific enolase as predictors of neurological outcome in patients after cardiac arrest and return of spontaneous circulation: a systematic review

Out-of-Hospital Cardiac Arrest –Optimal Management

Development of a prompt model for predicting neurological outcomes in patients with return of spontaneous circulation from out‐of‐hospital cardiac arrest

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