Biochemical markers in inbred strains of the rat (Rattus norvegicus)

Bender, Klaus; Adams, Mark A.; Baverstock, P. R.; Bieman, M. Den; Bissbort, S.; Brdička, R; Butcher, Geoffrey W.; Cramer, Donald V.; Deimling, Otto von; Festing, Michael F. W.; Günther, Eberhard; Guttmann, Ronald D.; Hedrich, Hans J.; Kendall, P. B.; Kluge, R; Moutier, R; Simon, Babette; Womack, James E.; Yamada, Junzo; Zutphen, Bert van

doi:10.1007/bf00364769

Cited by 64 publications

(27 citation statements)

References 27 publications

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“…9 -14 SHRs are also immunologically depressed because they possess fewer than normal thymodependent lymphocytes, which are involved in a delayed type of hypersensitivity and allograft rejection. 20 and are thus histoincompatible. We therefore designed an experimental allograft model with SHRs and WKYs to study the interaction of genetically determined immune response, high blood pressure, and smooth muscle cell proliferation with arterial wall injury and response during graft rejection without immunosuppression.…”

mentioning

confidence: 97%

Allograft-induced arterial wall injury and response in normotensive and spontaneously hypertensive rats.

Plissonnier

Lévy

Salzmann

et al. 1991

Arterioscler Thromb

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The role of genetically determined immune attack and blood pressure in graft rejectioninduced arterial wall injury and response was assessed by studying the compliance and changes in wall structure of aortic isografts and allografts in normotensive (Wistar-Kyoto [WKY]) and hypertensive (spontaneously hypertensive [SHR]) rats. Six groups of 8-week-old rats were compared: sham-operated in both strains, isografts, and allografts between the two strains (SHR aortas grafted in WKYs, designated SWs; WKY aortas grafted in SHRs, designated WSs; isografts in SHRs, designated SSs; and isografts in WKYs, designated WWs). Each arterial graft was studied 8 weeks after transplantation for volume and compliance (pressures of 75-175 mm Hg) under basal conditions. The amounts of collagen, elastin, and nuclei in the media and intima of the walls of control and grafted aortas were quantified morphometrically. Isografts and controls had the same mechanical characteristics under basal conditions: the arterial volume and arterial compliance of hypertensive rats were lower than those of normotensive rats (/?<0.001). Allografts had a greater initial volume (/><0.001) and a lower compliance (p< 0.001) than did isografts. Allografts in SHRs (SSs) were initially dilated, whereas allografted WKYs (WWs) were not There was intimal proliferation in hypertensive isografts (14±0.77 /tin) and in both types of allografts (WS, 69±1.55 /tm; SW, 44±1.81 /tin); nucleus density was higher in hypertensive allografts (WS) than in normotensive allografts (SW); and collagen density was also higher in SW than in WS allografts. Allografts had decreased medial thickness and decreased smooth muscle cell density. Medial thickness and the absolute amounts of elastin and collagen were significantly lower in SWs than in WSs. Rejection of the arterial graft had major effects on arterial wall injury and response in both strains. The thickness and composition of the intimal proliferative response was mainly correlated with the genetically determined blood pressure and smooth muscle cell proliferative potential. In contrast, differences in the medial structural changes of SWs and WSs were correlated mainly with the genetically determined immune process. Functional changes were therefore related to changes in both intimal and medial structure. (Arteriosclerosis and Thrombosis 1991;ll:1690-1699)

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mentioning

confidence: 97%

Allograft-induced arterial wall injury and response in normotensive and spontaneously hypertensive rats.

Plissonnier

Lévy

Salzmann

et al. 1991

Arterioscler Thromb

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“…Although LL females also showed preferences for compatible benefits between BB and the F1 hybrid male rats, they chose male urine of genetically identical LL rats over that of BB or the F1 hybrid rats at the cost of inbreeding. Male pheromone levels might be positively correlated with genetic quality in male animals, and thus signal the information to choosy females about genetic benefits, such as "good genes" and sexy son benefits [4,5,11,13,15,23,26,28]. Preferences for genetic compatibility strictly depend on the interplay of the genotypes of potential partners and are different from directional preferences for ornamental secondary sexual traits [4,7].…”

Section: Discussionmentioning

confidence: 99%

“…Individuals of an inbred strain are nearly genetically identical to each other (like identical twins), but genetically distinct across different inbred strains [26,27]. The reciprocal hybrids share the same complement of genes, and have intermediate relatedness between the two parental strains.…”

Section: Introductionmentioning

confidence: 99%

A male pheromone-mediated trade-off between female preferences for genetic compatibility and sexual attractiveness in rats

Zhang

2014

Front Zool

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Introduction: Chemosensory signals play a vital role in socio-sexual interactions of rodents. Females rely heavily on chemosensory signals to evaluate genetic similarity and quality of potential mates, but their olfactory preferences for these criteria often conflict in mate choice. Results: Using two inbred strains of rats, Brown Norway (BB) and Lewis (LL) and their F1 reciprocal hybrids (BL, BB♀ breed with LL♂; LB, LL♀ breed with BB♂) as genetic models, we found that the chemosensory preferences of BB and LL females between these 4 strains of rats could be predicted on the basis of genetic compatibility benefits, except that LL females exhibited incestuous preferences for male urine odor of LL rats over that of the BB strain and the F1 hybrids. Seven ketone components of major urine volatiles proved to be potential male pheromones and were enriched in LL males compared to BB males or the F1 hybrid males. We hypothesize that these ketones produced an extravagant male trait that attracts LL females, overriding compatibility traits. This conclusion was corroborated by adding three synthetic pheromone analogues, 4-heptanone, 2-heptanone and 9-hydroxy-2-nonanone of these 7 components, which resulted in equalization of the sexual attractiveness of BB male urine and LL male urine. Additionally, in the genetically diverse F2 hybrids (BL♀ breed with BL♂), the pheromones-enriched males could consistently attract the F2 females. Conclusions: We suggest that the exaggerated male pheromones serve as a "sexual chemical ornament" to attract females, independent of genetic compatibility, whereas genetic dissimilarity could influence the preferences only when male pheromones varied on a small scale.

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“…Biochemical techniques based on the electrophoretic demonstration of polymorphisms of body proteins have revealed a considerable number of reliable genetic markers (Bender et at., 1984), but are technically complicated and time consuming. The immunoassay which we used has the advantage over previous techniques of being simple to perform and economical.…”

Section: Discussionmentioning

confidence: 99%

Genetic monitoring of rat strains using monoclonal antibodies specific for polymorphic class I and class II MHC antigens

Fernández¹,

Weeks²

1988

Lab Anim

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Biochemical markers in inbred strains of the rat (Rattus norvegicus)

Cited by 64 publications

References 27 publications

Allograft-induced arterial wall injury and response in normotensive and spontaneously hypertensive rats.

Allograft-induced arterial wall injury and response in normotensive and spontaneously hypertensive rats.

A male pheromone-mediated trade-off between female preferences for genetic compatibility and sexual attractiveness in rats

Genetic monitoring of rat strains using monoclonal antibodies specific for polymorphic class I and class II MHC antigens

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