Biochemical markers in gastrointestinal malignancies

Cooper, Edward H.; Giles, G. R.

doi:10.1007/978-1-4613-2833-9_1

Cited by 16 publications

(2 citation statements)

References 90 publications

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“…Além dos métodos radiológicos e endoscópicos, tem-se ampliado o estudo de marcadores tumorais, com o intuito de melhor avaliar o diagnóstico, o prognóstico e o acompanhamento dos doentes com câncer (15) . Os principais marcadores tumorais séricos utilizados na prática clínica no câncer gástrico são: CEA (4,12,17) e CA72-4 (6,7,9,22) . Estes marcadores são determinados na maioria das vezes no soro, na ocasião do diagnóstico e no acompanhamento clínico.…”

Section: Introductionunclassified

CA72-4 e CEA no soro e no lavado peritonial de doentes com câncer gástrico

Mandorwski

Lourenço

Forones

2002

Arq. Gastroenterol.

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Section: Introductionunclassified

CA72-4 e CEA no soro e no lavado peritonial de doentes com câncer gástrico

Mandorwski

Lourenço

Forones

2002

Arq. Gastroenterol.

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“…The two controls with high CEA levels were smokers, and this can explain the high level of this marker 24 . It is accepted that assays detecting the CA15-3 are more sensitive than those detecting CEA and are more often used in diagnosing this disease, but the combined use of the two types of assays can be more effective 11,12 .…”

Section: Ca15-3mentioning

confidence: 97%

Evaluation of preoperative predictive values of serum CA15-3 and CEA within Sudanese women with breast cancer.

Ahmed¹,

Hussein²

2009

Sud Jnl Med Sci.

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Objectives: Early detection of cancer comprises early diagnosis in symptomatic and screening of asymptomatic individuals. Our aim was to evaluate the significant values of carbohydrate antigen 15-3 (CA15-3) and/or Carcinoembryonic antigen (CEA) in women with breast cancer. Design and setting: This case control study was conducted in Khartoum Teaching Hospital, Khartoum, Sudan. Application of such measurement may be helpful within screening and early detection efforts in such a country like Sudan with poor resources. Methods: We examined by serological radioimmuno-assay methods, significant elevation of CA15-3 and CEA serum samples obtained from 100 women of whom 40% and 35% were patients with histopathologically confirmed breast cancer and benign breast lumps respectively and the remaining 25% were apparently healthy controls. Statistical analysis: Data were analyzed by using a computer SPSS program. Results: Among the 75 patients with breast lumps, 33 (44%) and 31(37.3%) showed high CA15-3 and CEA levels respectively. Of the 40 carcinomas, high expressions of CA15-3 and CEA were found among 28(70%) and 24(60%) respectively. Notably, only 2(8%) of the controls showed lightly elevated CEA. Conclusions: The obtained Specificity of 85.7%, 80% and sensitivity of 70%, 60% for CA15-3 and CEA correspondingly, support the combined application of both markers in screening for breast cancer.

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Molecular biology of proto-oncogenes in genitourinary cancers

Peehl¹

1987

Cancer

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The application of molecular biology to oncology has allowed the recognition of altered genes in cancer cells. The DNA sequences most commonly altered belong to the family of proto-oncogenes, which are homologous to the cancer-causing genes of RNA tumor viruses. In the normal cell, proto-oncogenes apparently have important functions in regulation of growth and differentiation. When altered by mutation, deletion, translocation or amplification in cancer cells, proto-oncogenes may disrupt fundamental cellular processes. Such aberrant functioning by abnormal protooncogenes may play crucial and even causative roles in cancer development. Altered protooncogenes have been identified in cancers of the human urogenital tract. Studies on the expression of proto-oncogenes in genitourinary cells will increase understanding of basic biological properties of these cells, and may yield information relevant to staging, diagnosis, risk factors, and markers of pathologic classification.Cancer 60:645-649, 1987.N 1979, oncology took a dramatic turn along the path of

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Biochemical markers in gastrointestinal malignancies

Cited by 16 publications

References 90 publications

CA72-4 e CEA no soro e no lavado peritonial de doentes com câncer gástrico

CA72-4 e CEA no soro e no lavado peritonial de doentes com câncer gástrico

Evaluation of preoperative predictive values of serum CA15-3 and CEA within Sudanese women with breast cancer.

Molecular biology of proto-oncogenes in genitourinary cancers

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