Biochemical indices of human vitamin C status

Jacob, Robert A.; Skala, J. H.; Omaye, Stanley T.

doi:10.1093/ajcn/46.5.818

Cited by 120 publications

(59 citation statements)

References 25 publications

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“…Serum vitamin C reflects recent intake of the vitamin (24), and thus a single serum vitamin C measurement, as used in the present study, could misclassify many individuals with respect to their long-term intake (25). However, in the present study blood samples were obtained from children and parents on the same day, so their serum levels would be expected to reflect the intake during same period for both parents and children.…”

Section: Discussionmentioning

confidence: 96%

Fruit and vegetable intake: vitamin C and beta-carotene intake and serum concentrations in six-year-old children and their parents

Þórsdóttir¹,

Gunnarsdottir²,

Ingolfsdottir³

et al. 2006

Food & Nutrition Research

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Background : Intake of fruit and vegetables, which are important sources of antioxidant nutrients, has frequently been inversely related to the risk of chronic diseases. Objective : To investigate the serum concentration of vitamin C and b-carotene in relation to fruit and vegetable intake in 6-year-old children and their parents. Design : An observational study on families of healthy 6-year-old children in the Greater Reykjavik area. Serum vitamin C and b-carotene were analysed. Fruit and vegetable intake of children and their parents was assessed by 3 day weighed food records and by a food frequency questionnaire. Results : A positive correlation was seen in serum vitamin C concentration (r0/0.454 Á0.570, pB/0.005) and serum b-carotene concentration (r 0/0.385 Á0.497, pB/0.02) between family members. The total intake of fruit, vegetables and fruit juice was 1649/124 g (mean9/SD), 3029/181g and 2389/175 g for children, mothers and fathers, respectively. Family members' intake of fresh fruit, fruit juice and green leafy vegetables was positively related (r 0/0.227, pB/0.02 and r 0/0.313, pB/0.01 between children and their mother and father, respectively, and r 0/0.247, pB/0.05 between parents). Conclusions : The relationship between children's and their parents' fruit and vegetable intake is supported in the present study by an even stronger correlation of serum vitamin C and b-carotene between family members. Interventions aimed at increasing fruit and vegetable consumption by children should focus on the whole family.

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Section: Discussionmentioning

confidence: 96%

Fruit and vegetable intake: vitamin C and beta-carotene intake and serum concentrations in six-year-old children and their parents

Þórsdóttir¹,

Gunnarsdottir²,

Ingolfsdottir³

et al. 2006

Food & Nutrition Research

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“…However, the comparison between the effects of fruit and vegetable intake may not be valid in our study because the frequency distributions of fruit and vegetable intake were markedly different. Since the vitamin C concentration in serum or plasma reflects dietary intake for several previous months, 38 it may be a more accurate marker of usual intake than dietary assessment by the FFQ and hence may be preferred when such an association with cardiovascular diseases is examined. 9 Serum vitamin C concentration varies seasonally, 39 and the variation over a period of years has not been well established.…”

Section: Yokoyama Et Al Serum Vitamin C and Incidence Of Stroke 2291mentioning

confidence: 99%

Serum Vitamin C Concentration Was Inversely Associated With Subsequent 20-Year Incidence of Stroke in a Japanese Rural Community

Yokoyama

Date

Kokubo

et al. 2000

Stroke

108

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Background and Purpose-Epidemiological evidence suggests that vitamin C may decrease the risk of stroke. The purpose of the present study was to examine the association of serum vitamin C concentration with the subsequent incidence of stroke. Methods-In a Japanese rural community, a cohort of 880 men and 1241 women aged 40 years and older who were initially free of stroke was examined in 1977 and followed until 1997. The baseline examination included a measurement of serum vitamin C concentration. The incidence of stroke was determined by annual follow-up examinations and registry. Results-During the 20-year observation period, 196 incident cases of all stroke, including 109 cerebral infarctions and 54 hemorrhagic strokes, were documented. Strong inverse associations were observed between serum vitamin C concentration and all stroke (sex-and age-adjusted hazard ratios were 0.93, 0.72, and 0.59, respectively, for the second, third, and fourth quartiles compared with the first quartile; P for trendϭ0.002), cerebral infarction (0.71, 0.59, and 0.51; P for trendϭ0.015), and hemorrhagic stroke (0.89, 0.75, and 0.45; P for trendϭ0.013). Additional adjustments for blood pressure, serum total cholesterol, body mass index, physical activity, smoking, alcohol drinking, antihypertensive medication, atrial fibrillation, and history of ischemic heart disease did not attenuate these associations markedly. Conclusions-Serum vitamin C concentration was inversely related to the subsequent incidence of stroke. This relationship was significant for both cerebral infarction and hemorrhagic stroke. Additional mechanistic hypotheses may be required to explain our findings.

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“…Leucocytes have been used for assessment of vitamin C (37), magnesium (18), and zinc (59) in sedentary people but not in athletes. Lymphocyte culture methods also have been introduced as a means for assessing nutritional status (71), but this method still requires better validation even in sedentary people.…”

mentioning

confidence: 99%

Indicators of Vitamin and Mineral Status in Athletes' Blood: A Review

Fogelholm¹

1995

International Journal of Sport Nutrition

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This review examines the hypothesis that vitamin and mineral status in athletes is inadequate for optimal sports performance. The review is based on indicators determined from blood and on studies published since 1980. Most of the studies did not find micronutrient status in athletes to be different from untrained controls. The serum fenitin concentration in females was lower than in males (27 vs. 78 yg . L-I), and the prevalence of low serum ferritin concentration was higher in female athletes than in untrained female controls (37 vs. 23%). Supplementation of water-soluble vitamins and iron was associated with an improvement in the corresponding indicators. Excluding a few studies with mildly anemic subjects, improvements in indicators of micronutrient status were not associated with enhanced athletic performance. Consequently, the levels of indicators of micronutrient status seen in athletes' blood were apparently compatible with optimal physical performance.

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Biochemical indices of human vitamin C status

Cited by 120 publications

References 25 publications

Fruit and vegetable intake: vitamin C and beta-carotene intake and serum concentrations in six-year-old children and their parents

Fruit and vegetable intake: vitamin C and beta-carotene intake and serum concentrations in six-year-old children and their parents

Serum Vitamin C Concentration Was Inversely Associated With Subsequent 20-Year Incidence of Stroke in a Japanese Rural Community

Indicators of Vitamin and Mineral Status in Athletes' Blood: A Review

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