Biochemical-imagistical prediction of biliary etiology for acute pancreatitis (A.S.ALT-CBD score)

Zarnescu, Narcis; Zarnescu, Eugenia Claudia; Costea, Radu; Neagu, S

doi:10.1016/j.pan.2017.05.326

Cited by 1 publication

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“…In men worldwide, factors such as smoking, alcohol, abdominal obesity, and diabetes account for the overall increased risk of developing AP. Women on the other hand, show a greater risk of biliary pancreatitis and post-endoscopic retrograde cholangiopancreatography pancreatitis [10] , [11] . Sex differences in AP may arise due to anatomical differences in pancreas size between men and women.…”

Section: Discussionmentioning

confidence: 99%

Impact of sex and comorbid diabetes on hospitalization outcomes in acute pancreatitis: A large United States population-based study

Weissman

Pandol

Ghaffar

et al. 2023

AIMSPH

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<abstract><sec> <title>Backgrounds</title> Data on the association between comorbid diabetes mellitus (DM) and acute pancreatitis (AP) remains limited. Utilizing a large, nationwide database, we aimed to examine the impact of comorbid diabetes mellitus on patients admitted for acute pancreatitis. </sec><sec> <title>Methods</title> This was a retrospective case-control study of adult patients with AP utilizing the National Inpatient Sample from 2015–2018, using ICD–10 codes. Hospitalization outcomes of patients admitted for AP with comorbid DM were compared to those without comorbid DM at the time of admission. The primary outcome was a mortality difference between the cohorts. Multivariable-adjusted cox proportional hazards model analysis was performed. Data was analyzed as both sex aggregated, and sex segregated. </sec><sec> <title>Results</title> 940,789 adult patients with AP were included, of which 256,330 (27.3%) had comorbid DM. Comorbid DM was associated with a 31% increased risk of inpatient mortality (aOR: 1.31; p = 0.004), a 53% increased risk of developing sepsis (aOR: 1.53; p = 0.002), increased hospital length of stay (LOS) (4.5 days vs. 3.7 days; p < 0.001), and hospital costs ($9934 vs. $8486; p < 0.001). Whites admitted for AP with comorbid DM were at a 49% increased risk of mortality as compared to Hispanics (aOR: 1.49; p < 0.0001). Different comorbidities had sex-specific risks; men admitted for AP with comorbid DM were at a 28% increased risk of mortality (aOR: 1.28; p < 0.0001) as compared to women. Men with comorbid DM plus obesity or hypertension were also at increased risk of mortality as compared to women, whereas women with comorbid DM plus renal failure were at greater risk of mortality as compared to men. </sec><sec> <title>Conclusions</title> Comorbid DM appears to be a risk factor for adverse hospitalization outcomes in patients admitted for AP with male sex and race as additional risk factors. Future prospective studies are warranted to confirm these findings to better risk stratify this patient population. </sec></abstract>

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Section: Discussionmentioning

confidence: 99%