Biochemical, histological and echocardiographic changes during experimental cardiomyopathy in STZ-induced diabetic rats

Akula, Annapurna; Krishna, Kota Murali; Gopisetty, S.G; Chitrapu, Ravi Venkatachelam; Madan, K.; Kalagara, S; Veeravalli, Krishna Kumar; Gomedhikam, J.P.

doi:10.1016/s1043-6618(03)00191-9

Cited by 67 publications

(75 citation statements)

References 29 publications

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“…Fractional shortening in our guineapigs had a mean 35.62 Ϯ3.62. The FS of the left ventricular values observed in this study was comparable with the data obtained by Yang et al (1999) in mice, rats (Akula et al 2003) (Table 4) and rabbits (33.35±0.8%) (Çetin et al 2001).…”

Section: Discussionsupporting

confidence: 90%

Echocardiographic variables in healthy guineapigs anaesthetized with ketamine–xylazine

Çetin

Toker

2005

Lab Anim

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Section: Discussionsupporting

confidence: 90%

Echocardiographic variables in healthy guineapigs anaesthetized with ketamine–xylazine

Çetin

Toker

2005

Lab Anim

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“…Studies have shown that treatment with STZ causes derangement of lipid profile. Alteration in lipid metabolism can also alter heart function by modifying the structure of cardiac plasma and subcellular membranes [20]. The present study showed an increase in the triglyceride levels of diabetic animals.…”

Section: Discussionsupporting

confidence: 58%

“…There are reports where STZ-induced diabetes have shown long-term effects on the ECG, systolic performance, rate of change of ventricular pressure, mean blood pressure and QT values in rats [20,22,23]. The present study showed increase in mean blood pressure in STZ injected rats whereas the other groups showed the normal mean blood pressure.…”

Section: Discussioncontrasting

confidence: 42%

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Commiphora mukul Prevents Myocardial Dysfunction in Streptozotocin Induced Diabetic Rats

Barve¹,

Bhonsle²

2014

TOPHARMCJ

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Abstract:The objective of this study is to evaluate the effect of ethyl acetate extract of Commiphora mukul (guggul) (EACM) in streptozotocin (STZ) induced diabetic cardiomyopathy in rats. Diabetes was induced in rats with STZ (45 mg/kg, i.p). The animals were divided in four groups: I-normal control, II-diabetic control, III-diabetic animals treated with EACM (400 mg/kg/day, p.o) and IV-normal animals treated with EACM (400 mg/kg/day, p.o).Cardiomyopathy developed after eight weeks of induction of diabetes. The biochemical parameters (glucose, triglycerides, cholesterol, LDL, HDL, CKMB, LDH) were evaluated at regular intervals. The hemodynamic measurements (LVDEP, Mean BP, Max dP/dT, Min dP/dT, ST segment and QT interval) were done on the 8 th week. Standardized EACM contained 3.36% w/w of guggulsterones. There were significant changes observed in the biochemical, hemodynamic and histological parameters of diabetic animals indicating induction of diabetic cardiomyopathy, whereas diabetic animals treated with EACM for eight weeks showed significant improvement in these parameters which serve as diabetic and cardiac markers. The present study reveals that EACM is effective in preventing diabetes induced myocardial dysfunction. This might be due to its efficacy in (a) normalizing the metabolic disturbances by acting as Farnesoid X receptor antagonist (FXR) or PPAR-alpha and PPAR-gamma agonist thereby regulating the lipid and glucose metabolism, (b) having a cardioprotective effect through various mechanisms such as regulation of endothelial nitric oxide synthase (eNOS), angiotensin type 2 receptor expression etc or (c) both. Thus, guggul might be a promising candidate to be evaluated for clinical efficacy in diabetic patients for the prevention of cardiomyopathy.

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“…De fato, observou-se atenuação da disfunção diastólica e preservação da função sistólica, sugerindo que o coração do diabético é, de fato, resistente a essa injúria isquêmica. Alguns investigadores têm demonstrado anormalidades na função sistólica e diastólica em humanos e em ratos diabéticos (Di Bonito, et al, 1996;Akula, et al, 2003;De Angelis, et al, 2000). Em nosso laboratório, demonstramos recentemente que animais diabéticos por STZ apresentavam alterações estruturais, na função sistólica e diastólica em 30 dias após a indução, avaliadas tanto pelo ecocardiograma quanto pela cateterização do VE (Wichi, et al, 2007).…”

Section: Avaliações Metabólicasunclassified

Modulação da viabilidade de fibroblastos cardíacos em cultura frente a hipóxia: papel de diferentes concentrações de glicose

Malfitano¹

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Biochemical, histological and echocardiographic changes during experimental cardiomyopathy in STZ-induced diabetic rats

Cited by 67 publications

References 29 publications

Echocardiographic variables in healthy guineapigs anaesthetized with ketamine–xylazine

Echocardiographic variables in healthy guineapigs anaesthetized with ketamine–xylazine

Commiphora mukul Prevents Myocardial Dysfunction in Streptozotocin Induced Diabetic Rats

Modulação da viabilidade de fibroblastos cardíacos em cultura frente a hipóxia: papel de diferentes concentrações de glicose

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