Biochemical Effects of Methanolic Extracts of Vernonia amygdalina and Gongronema latifolia on Alloxan-induced Diabetic Rats

Aba, Patrick; Okenwa-Ani, Chidiebere

doi:10.9734/bjpr/2016/22122

Cited by 6 publications

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“…Groups treated with combination of glibenclamide and G. latifolium particularly showed remarkable decreases in the MDA levels, increases in glutathione values and catalase activities 21 days PT. This result is in agreement with the reports of Aba and Okenwa-Ani (2015) who noted the ameliorative effects of either the glibenclamide or the G .latifolium on oxidative stress markers.…”

Section: Discussionsupporting

confidence: 93%

“…Synergistic hypoglycaemic actions of G. latifolium with other agents have been earlier reported (Aba and Okenwa-Ani, 2015). The observation of severe hypoglycaemia in the group treated with the combination after 21 days is a pointer that subchronic treatment with the two agents might pose hypoglycaemic treat to diabetics at the tested doses.…”

Section: Discussionmentioning

confidence: 59%

“…It is used culinarily in Igbo land, south eastern Nigeria (Edet et al, 2011) and in traditional medicine in treatment of certain ailments. Several researched studies have also demonstrated the antihyperglycaemic activities of the plant extract (Sakihama et al, 2002;Aba and Okenwa-Ani, 2015). assessed 1 h, 3 h, 6 h, 24 h, 7 days, 14 days and 21 days post treatment.…”

Section: Introductionmentioning

confidence: 95%

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Glycaemic, Lipidaemic and Antioxidant Profiles of Alloxan-Induced Diabetic Wistar Rats Treated with Glibenclamide and Aqueous Extract of <i>Gongronema latifolium</i> (Benth)

Emeka

2016

Not Sci Biol

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The current study investigated the ameliorative effects of combined therapy of glibenclamide and G. latifolium (GL) on several biochemical parameters of alloxaized Wistar rats. Thirty adult male Wistar rats assigned into 5 groups of 6 rats each were used for the study. Groups 2-5 were intraperitoneally injected with 160 mg/kg of alloxan monohydrate and upon establishment of diabetes (Fasting Blood Glucose (FBG) ≥ 126 mg/dl) were treated with 10 ml/kg distilled water (DW), 2 mg/kg glibenclamide, 200 mg/kg GL and 2 mg/kg glibenclamide and 200 mg/kg GL respectively. Rats in group 1 were not made diabetic and served as normal control. All the treatments were realized through daily oral route using gastric tube, for 21 days. Results indicated that the treatment of diabetic rats with a combination of glibenclamide and GL significantly reduced the elevated glucose levels, cholesterol, triacylglycerol, low density lipoprotein and malondialdehyde levels, along with increases in the high density lipoprotein, glutathione values and catalase activities, when compared to diabetic untreated group. It was concluded that the combined therapy of glibenclamide and GL showed superior antihyperglycemic, hypolipidaemic and antioxidant effects compared to either of them used alone.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 59%

Section: Introductionmentioning

confidence: 95%

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Glycaemic, Lipidaemic and Antioxidant Profiles of Alloxan-Induced Diabetic Wistar Rats Treated with Glibenclamide and Aqueous Extract of <i>Gongronema latifolium</i> (Benth)

Emeka

2016

Not Sci Biol

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Hypoglycemic Potential of African Medicinal Plants in Diabetic and Non-Diabetic Human Subjects: A Review

Mohammed

2023

Clinical Complementary Medicine and Pharmacology

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Comparative hypoglycemic potentials and phytochemical profiles of 12 common leafy culinary vegetables consumed in Nsukka, Southeastern Nigeria

Emeka

Udechukwu

2018

Journal of Basic and Clinical Physiology and Pharmacology

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Background Metabolic disease like diabetes mellitus is on the increase in developing countries due to lack of access to orthodox medicine owing to its high cost. Health benefits of culinary vegetables cannot be overemphasized. This study therefore aims to profile the hypoglycaemic potentials of 12 common leafy vegetables consumed in Nsukka, Southeastern Nigeria and advise diabetic patients accordingly. Methods A total of 75 albino Wistar rats assigned to 15 groups of five rats per group were used for the study. Diabetes was induced in groups 1-14 rats by intraperitoneal injection of alloxan monohydrate (160 mg/kg), and rats in group 15 were not made diabetic. Groups 1-12 rats were treated with aqueous extracts of the vegetables (200 mg/kg), and group 13 rats received glibenclamide at 2 mg/kg and served as standard control. Rats in groups 14 and 15 received distilled water (10 mL/kg) to serve as negative and normal controls, respectively. The fasting blood glucose (FBG) values of the rats were determined 3, 6 and 24 h post-treatment. Phytochemical studies on the vegetables were also carried out. Results Results revealed that the hypoglycaemic activities of Gongronema latifolium, Pterocarpus santalinoides, Ocimum gratissimum, Pterocarpus mildbraedii and Vernonia amygdalina were comparable (p>0.05) to that obtained for glibenclamide (standard anti-diabetic drug) while Gnetum africanum and Piper guineense did not show significant hypoglycaemic activities. Phytochemicals such as flavonoids, alkaloids, tannins, saponins, glycosides, and terpenes were present in the vegetables. Conclusions It was concluded that the vegetables possess hypoglycaemic activities at different capacities with G. latifolium being the most potent.

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Biochemical Effects of Methanolic Extracts of Vernonia amygdalina and Gongronema latifolia on Alloxan-induced Diabetic Rats

Cited by 6 publications

References 0 publications

Glycaemic, Lipidaemic and Antioxidant Profiles of Alloxan-Induced Diabetic Wistar Rats Treated with Glibenclamide and Aqueous Extract of <i>Gongronema latifolium</i> (Benth)

Glycaemic, Lipidaemic and Antioxidant Profiles of Alloxan-Induced Diabetic Wistar Rats Treated with Glibenclamide and Aqueous Extract of <i>Gongronema latifolium</i> (Benth)

Hypoglycemic Potential of African Medicinal Plants in Diabetic and Non-Diabetic Human Subjects: A Review

Comparative hypoglycemic potentials and phytochemical profiles of 12 common leafy culinary vegetables consumed in Nsukka, Southeastern Nigeria

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