Biochemical effects of 3,5-diethoxycarbonyl-1, 4-dihydrocollidine in mouse liver

Gayathri, A; Padmanaban, Govindarajan

doi:10.1016/0006-2952(74)90042-2

Cited by 9 publications

(7 citation statements)

References 32 publications

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“…When amino acid incorporation by ribosomes in vitro was measured, a slight increase was found 6h after treatment with the drug, though the increase was not statistically significant (S. Gamulin & M. R. Norman, unpublished work). After 2 days of treatment with 3,5-diethoxycarbonyl-1 ,4-dihydrocollidine, Gayathri &Padmanaban (1974) found a significant increase in amino acid incorporation by ribosomes of treated mice, though they found decreased incorporation with treatment lasting more than 2 days.…”

Section: Discussionmentioning

confidence: 91%

Ribosome function in livers of porphyric mice

Favero

Gamulin

Gray

et al. 1975

Biochemical Journal

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Section: Discussionmentioning

confidence: 91%

Ribosome function in livers of porphyric mice

Favero

Gamulin

Gray

et al. 1975

Biochemical Journal

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“…The mode of action of DDC in porphyrinogenesis is alkylation of liver cytochrome P450 and inhibition of ferrochelatase by the cytochrome P450-derived N-alkyl porphyrin [17]. In the present study, a small amount of protoporphyrin accumulated in the livers of P. leucopus that were treated with DDC, but a lack of protoporphyrin accumulation was noted in P. maniculatus and Microtus pennsylvanicus.…”

Section: Discussionmentioning

confidence: 99%

Hepatic porphyria induced by the herbicide tralkoxydim in small mammals is species‐specific

Pauli

Kennedy

2005

Enviro Toxic and Chemistry

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Tralkoxydim is the active ingredient in a postemergent herbicide used in cereal crops. During preregistration trials, tralkoxydim was observed to cause hepatic porphyria and cholestasis in laboratory mice. Porphyria was not seen in similarly exposed rats or hamsters, but data were not collected regarding the susceptibility of any wild small mammal species to the tralkoxydim-induced porphyria. To address this data gap, we exposed small mammals to tralkoxydim, to 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC; a known porphyrinogenic chemical), or to sunflower oil alone. We studied small mammal species that might be exposed following agricultural applications of the herbicide, including the white-footed mouse (Peromyscus leucopus), the deer mouse (P. maniculatus), and the meadow vole (Microtus pennsylvanicus). Because of their known susceptibility to both tralkoxydim- and DDC-induced porphyria, commercially supplied Mus musculus (CD-1 Swiss mice) were exposed as positive-control animals. We also exposed offspring of wild-caught M. musculus to compare their responses to those of the commercially supplied animals. Potential hepatotoxicity was determined by assessing the accumulation of liver protoporphyrin. Of the species tested, only M. musculus was susceptible to the porphyrinogenic action of tralkoxydim, and no significant accumulation of protoporphyrin was observed in any of the other species exposed to the herbicide.

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“…This protocol cannot remove precipitates of porphyrins, such as those modeled in animals treated with DDC diet to induce porphyrin accumulation and severe cholestasis ( Gayathri and Padmanaban, 1974 ).…”

Section: Limitationsmentioning

confidence: 99%