Biochemical Effect of Thyroid Hormones on Heart Failure

Abstract

Thyroid hormones and heart-failure disease (HF) are inextricably linked, as the fact has been established the thyroid causes heart muscle weakness. The goal of the study estimates the link of thyroid hormones and the risk of heart failure disease by measuring T4, T3, fT4, fT3, cholesterol, TG, HDL, LDL, VLDL and BMI in serum of 65 patients of heart failure disease and 40 control group. The results showed a decrease significantly in the concentration of T4, T3, fT4, fT3 and HDL compared to the healthy group at P≤0.001 (53.88±29.5 nmol/ml), P=0.02 (1.77±0.8 nmol/ml), P≤0.001 (8.94±4.1 pmol/ml), P≤0.001(2.85±1.5 pmol/ml) and P≤0.001(31.13±8.2 mg/dL), respectively. Further, there was a significant increase in total cholesterol concentration, TG, LDL, VLDL and BMI compared to the healthy group at P≤0.001 (348.16±87.6 mg/dL), P≤0.001 (172.41±52.9 mg/dL) P≤0.001 (303.22±117.3 mg/dL), P≤0.001 (34.48±10.6 mg/dL) and P≤0.001 (28.68±4.5 Kg/m 2 ), respectively. The study showed that there is a strong correlation between thyroid hormones and total cholesterol, LDL with high BMI. Therefore, we conclude that thyroid hormones spatially fT3 is a new indicates the increase of heart failure disease.