Biochemical, DNA and Electron Microscopic Changes in Carbamate Exposed Workers

Singh, Malti; Bhardwaj, Neetu; Kaur, Amandeep; Singh, Kuldip

doi:10.1080/09709274.2009.11906233

Cited by 2 publications

(1 citation statement)

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“…Carbamate exposure is linked to free radical generation, so it causes oxidative stress and various types of damages to biomolecules such as DNA, lipids, proteins etc. (25).Albendazole cytotoxic effect involves tubulin binding. The cytotoxic effect of ABZ usually involves binding to β-tubulin, it has been suggested that oxidative stress may also play a role in its parasitical mechanism.…”

Section: Resultsmentioning

confidence: 99%

Cytogenetic effects of albendazole on stem cells mice bone marrow

Muthana Ibrahim Maleek,

Damya Kareem Kadim

2022

JWSM

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This experiment was estimated percentage of chromosomal aberration (CAs), micronucleus` (MN) and mitotic index (MI) in bone marrow cells of mie laboratory as a way to measure/e Albendazole (ABZ) ability of the above variables. This study divided according to times injection and concentration of ABZ (200 and 400 mg / kg). Mice were divided into three groups included negative control I&II ( I no treated & II treated with 0.2 ml of normal saline), positive control split into two groups (one of them injected with ABZ 200 mg / kg, second with 400 mg / kg for 24 hours) and treatment groups. These groups are dividing to the sixth category according to concentration and period of treatment. Groups I&II (I the mouse were treated with ABZ three days 200 mg/kg for every day and II same period, but dose400mg/kg). Groups III&IV (III the mouse treated with two injection of ABZ 200 mg/kg first dose at zero day, and the second at seventh day and IV same period but dose 400mg/kg). Groups V&VI (V the mouse treated with two doses ABZ 200 mg/kg first three days, with one dose/one day and after seven days repeat three doses one dose /one days and VI same period, but the dose is 400mg/kg). The results showed that the ABZ drug led to significant increase in CA, MN and decrease in MI at (p<0.05). This percentage increases in conjunction with the length of the treatment period.

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Section: Resultsmentioning

confidence: 99%