Biochemical Pharmacology volume 80, issue 8, P1170-1179 2010 DOI: 10.1016/j.bcp.2010.07.007 View full text
Mathilde Bayet-Robert, Suzanne Lim, Chantal Barthomeuf, Daniel Morvan

Abstract: Marine plants and animals are sources of a huge number of pharmacologically active compounds, some of which exhibit antineoplastic activity of clinical relevance. However the mechanism of action of marine natural products (MNPs) is poorly understood. In this study, proton NMR spectroscopy-based metabolomics was applied to unravel biochemical disorders induced in human MCF7 breast cancer cells by 3 lead candidate anticancer MNPs: ascididemin (Asc), lamellarin-D (Lam-D), and kahalalide F (KF). Asc, Lam-D, and KF…

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