Biochemical correlates of in vivo cell-mediated immune dysfunction in patients with depression: A preliminary report

Hickie, Ian B.; Hickie, Catherine; Bennett, Barbara; Wakefield, Denis; Silove, Derrick; Mitchell, Philip B.; Lloyd, Andrew R.

doi:10.1016/0192-0561(95)00055-7

Cited by 23 publications

(10 citation statements)

References 23 publications

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“…This test comprises a convenient plastic applicator with 7 ubiquitous antigens (tetanus, diphtheria, streptococcus, tuberculin, candida, trichophyton, and proteus) and a glycerine control preloaded in eight tined heads (7). A decline in immune function, associated with severe (melancholic) depression (8,9), wintering in the Antarctic (10), and perceived distress (11), has been demonstrated using this apparatus.…”

Section: Introductionmentioning

confidence: 97%

“…Consequently, variations in responsiveness between individuals and/or those from different geographical locations observed in psychoneuroimmunology research may reflect differences in prior immunization or natural exposure rather than the effects of psychosocial factors (7,9,13). Interpretation of brain/immune relationships is therefore difficult.…”

Section: Introductionmentioning

confidence: 99%

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Influences of Distress and Alcohol Consumption on the Development of a Delayed-Type Hypersensitivity Skin Test Response

Smith

Vollmer‐Conna²,

Bennett³

et al. 2004

Psychosomatic Medicine

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Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Influences of Distress and Alcohol Consumption on the Development of a Delayed-Type Hypersensitivity Skin Test Response

Smith

Vollmer‐Conna²,

Bennett³

et al. 2004

Psychosomatic Medicine

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“…Depressed individuals show an increased number of leukocytes relative to control subjects [136][137][138]. Neutrophils and monocytes, specific types of leukocytes that engulf and destroy foreign cells, are also increased in depressed patients compared with controls [139][140][141][142]. In contrast to activation of components involved in the nonspecific immune response, depressed individuals show a blunted cell-mediated immune response, indicating immunosuppression [130,142,143].…”

Section: Immune System Dysfunctionmentioning

confidence: 87%

Depression and the cardiovascular system: increasing evidence of a link and therapeutic implications

Marano

Harnic

Lotrionte

et al. 2009

Expert Review of Cardiovascular Therapy

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This review explores the epidemiological evidence for the relationship between depression and cardiovascular disease from a mechanistic standpoint. It is important to examine the biological, behavioral and social mechanisms to improve outcomes for depressed cardiac patients. A number of plausible biobehavioral mechanisms linking depression and cardiovascular disease have been identified. Tricyclic antidepressants have various effects on the cardiovascular system, while selective serotonin reuptake inhibitors are not associated with adverse cardiac effects and should, therefore, be the preferred choice for the treatment of most patients with comorbid depression and cardiovascular disease.

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“…Lymphocytes possess receptors for neurotransmitters released from these nerves [35]. It has been suggested that patients with clinical depression have higher levels of catecholamines and glucocorticoids [36, 13]. Glucocorticoids have long been used as immunosuppressive and anti-inflammatory agents, and they have also been suggested to modulate the pattern of activation of T helper cells [37, 38].…”

Section: Discussionmentioning

confidence: 99%

“…Single studies investigating the association between depression and immune response show contradictory results [10, 11, 12, 13]which are probably explained by the small number of subjects studied, the lack of control for confounding variables, and different criteria used to define depression. Moreover, these studies are all cross-sectional in design and therefore make no allowance for within-individual variability of immune variables and/or change in depressive status.…”

Section: Introductionmentioning

confidence: 99%

Depressive Symptoms Lead to Impaired Cellular Immune Response

Fortes¹,

Farchi²,

Forastiére³

et al. 2003

Psychother Psychosom

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Background: The association between depression and immune response is not yet clear. The biological mechanisms by which depression alters the immune system is not yet understood. The purpose of this study was to investigate the longitudinal relationship between depressive symptoms and cellular immune response. Methods: A cohort study with a baseline measurement and three annual health assessments was set up in a residential home for elderly people in Rome, Italy. A total of 166 residents aged 65 years and older, mean age 81 years, were interviewed and blood samples were collected at each annual assessment. Percentage changes in lymphocytes and T-cell subsets related to depressive symptoms were estimated over a period of 4 years, using regression models for repeated measurements. Results: Elderly people with seven or more symptoms of depression, according to the Geriatric Depression Scale, had a lower percentage of CD4+DR+ T-cells over 4 years [β = –20.2; 95% confidence interval (CI) = –33.0 to –4.9] and CD8+DR+ T-cells (β = –26.9; 95% CI = –42.5 to –7.0) than elderly with less than seven symptoms of depression, after adjusting for confounding factors (sex, age, marital status, education, smoking habit, nutritional status, chronic diseases, disability and the use of benzodiazepines). Conclusion: The results of this study suggest an adverse effect of depressive symptoms on immune response. It remains to be determined whether these depression-associated immune changes are related to the onset or course of physical illness and the increased mortality observed in depressed old people.

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Biochemical correlates of in vivo cell-mediated immune dysfunction in patients with depression: A preliminary report

Cited by 23 publications

References 23 publications

Influences of Distress and Alcohol Consumption on the Development of a Delayed-Type Hypersensitivity Skin Test Response

Influences of Distress and Alcohol Consumption on the Development of a Delayed-Type Hypersensitivity Skin Test Response

Depression and the cardiovascular system: increasing evidence of a link and therapeutic implications

Depressive Symptoms Lead to Impaired Cellular Immune Response

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