Biochemical composition and metabolic pathways of filarial worms <i>Setaria cervi</i>: search for new antifilarial agents

Ahmad, Rumana; Srivastava, Arvind K.

doi:10.1017/s0022149x07799133

Cited by 18 publications

(11 citation statements)

References 143 publications

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“…rarely survives in the abnormal hosts and the microfilariae of Setaria spp. rarely can be identified in blood tests (Mohanty et al, 2000;Ahmad & Srivastava, 2007). The microfilariae of Setaria spp.…”

Section: Discussionmentioning

confidence: 99%

“…The microfilariae of Setaria spp. can develop in the central nervous system, eyes, heart, lymphatic system and under the skin, causing: abcesses, allergic reactions, lung inflammation, enlarged lymph nodes and eye lesions (Ahmad & Srivastava, 2007). Because the mosquito Armigeres sp.…”

Section: Discussionmentioning

confidence: 99%

“…that migrate into the cow's bloodstream. As they take blood meals, mosquitos can inject the parasite into abnormal hosts, such as deers, goats, horses and sheep, causing inflammation of the eyes, liver, lungs, lumbar paralysis or the often deadly cerebrospinal setariosis (Ahmad & Srivastava, 2007). Setaria spp.…”

Section: Discussionmentioning

confidence: 99%

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Subconjunctival infestation with Setaria

Ţălu

Ştefănuţ²,

Mihalca

et al. 2012

Helminthologia

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SummaryMost cases of human subconjunctival infestations with nematodes described in the literature belong to the genus Dirofilaria. This is a report of subconjunctival setariasis in a 65 years old man, diagnosed 2 years after a travel to Singapore. The parasite was removed immediately from the subconjunctival space and the patient was administered topical antibiotic and anti-inflammatory eye drops. The complete remission of symptoms and signs was noted. The parasite was identified on optical microscopy as belonging to the genus Setaria. The life cycle of the parasite and the accidental human contamination are described. The presence of a moving worm under the human conjunctiva is a rare condition that requires urgent action, in order to prevent its migration into less accessible locations. Since the human subject is a dead-end host who does not allow the multiplication of the parasite, its surgical removal is the only cure.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Subconjunctival infestation with Setaria

Ţălu

Ştefănuţ²,

Mihalca

et al. 2012

Helminthologia

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“…(Kadenatsii et al 1974). Usually studies are conducted on the bovine filarid S. cervi in laboratory models as this worm resembles the human species in having microfilarial periodicity and chemotherapeutic response to known antifilarial agents (Singhal et al 1973;Ahmad and Srivastava 2007).…”

Section: Introductionmentioning

confidence: 99%

In vitro evaluation of antifilarial effect of Azadirachta indica leaves extract in different solvents on the microfilariae of Setaria cervi

Kausar

2016

J Parasit Dis

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Polar solvent extracts of Azadirachta indica leaves were investigated to evaluate in vitro anthelmintic activity on the microfilariae of Setaria cervi. Four extracts of A. indica leaves were prepared with different solvents in increasing order of polarity (diethyl ether \ chloroform \ ethanol \ methanol). Stock solution of the extract of A. indica leaves was prepared in Ringer's solution at the concentrations of 50, 100 and 200 lg/ml and used against microfilariae in three replicates. Ringer's solution was used as experimental control. Mortality rates of microfilariae were recorded for each concentration after 45, 90 and 135 min, respectively. All the solvent extracts show significant anthelmintic activity at the concentration of 200 lg/ml after 135 min of incubation. Highest mortality rate of microfilariae was observed in methanol and ethanol extracts throughout the incubation period compared to chloroform and diethyl ether extracts which showed low mortality rates. Dose dependent effect of ethanol and chloroform showed highest and lowest ranking when analyzed by regression values and correlation of regression. Solvents extracts of A. indica leaves showed anthelmintic effect and therefore may be used as phytopharmacological agents in future.

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“…In view of the practical difficulties in procuring human strains of Wuchereria bancrofti and Brugia malayi for drug screening, the bovine filarial parasite S. cervi, resembling the human parasites in having microfilarial periodicity and chemotherapeutic response to known antifilarial agents, is widely used as a model to screen potential antifilarial agents (Ahmad and Srivastava 2007).…”

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confidence: 99%

Observations on in vitro and in vivo antimicrofilarial effects of Bishop’s weed (Trachispermum ammi)

Rizvi

Khan

et al. 2011

J Parasit Dis

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The antimicrofilarial efficacy of Trachispermum ammi extacts in vitro and in vivo using Setaria cervi as a model, was investigated. T. ammi seed extracts were prepared using different solvents (with increasing order of polarity of the solvent) including petroleum ether, diethyl ether, chloroform, ethyl acetate, acetone, ethanol, and methanol. The extracts were tested for in vitro antimicrofilarial activity. The ethanolic and the methanolic extracts showed maximum activity in causing flaccidity in the microfilariae. The extracts were potent even at concentrations as low as 5 ll/ml. When orally administered to experimentally infected rats, the extracts eliminated circulating microfilariae within 2 weeks. It is inferred that the antimicrofilarial molecule(s), are polar in nature. They induce flaccidity in the microfilariae, by possibly inhibiting monoamine oxidase. This communication supplements the ethnopharmacological information for the use of T. ammi as an antihelminthic, and indicates that T. ammi could be used as a potential source of antimicrofilarial drugs.

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Biochemical composition and metabolic pathways of filarial worms Setaria cervi: search for new antifilarial agents

Cited by 18 publications

References 143 publications

Subconjunctival infestation with Setaria

Subconjunctival infestation with Setaria

In vitro evaluation of antifilarial effect of Azadirachta indica leaves extract in different solvents on the microfilariae of Setaria cervi

Observations on in vitro and in vivo antimicrofilarial effects of Bishop’s weed (Trachispermum ammi)

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