Abstract:Tetrahydromethanopterin (H4MPT) is a tetrahydrofolate (H4F) analog that serves as a one‐carbon carrier cofactor in the methanogenesis pathway in methanogenic microorganisms. One major structural feature that distinguishes H4MPT from H4F and other pterin‐containing biomolecules is the presence of methyl groups at the C7 and C9 positions. Although the biosynthesis of H4MPT has been relatively well‐defined, the enzyme responsible for the methylation reactions at the unreactive carbon centers has remained unclear.… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.