Biochemical characterization of Peumus boldus fruits: Insights of its antioxidant properties through a theoretical approach

Otero, Carolina; Miranda-Rojas, Sebastián; Llancalahuén, Felipe M.; Fuentes, Juan A.; Átala, Cristian; González-Silva, Gloria; Verdugo, Diego; Sierra‐Rosales, Paulina; Moreno, Adrián A.; Gordillo-Fuenzalida, Felipe

doi:10.1016/j.foodchem.2021.131012

Cited by 4 publications

(3 citation statements)

References 38 publications

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“…Of these, chrysin was upregulated extremely significantly in all three periods (Log 2 FC = 12.17, GR; Log 2 FC = 13.81, BR+3; Log 2 FC = 8.07, BR+9). Chrysin has been shown to have antioxidant capacity and can scavenge free radicals, is anti-inflammatory, and has demonstrated other activities [40], but it has been less studied in tomatoes. The genes associated with flavonoid biosynthesis are mainly classified into structural and regulatory genes [41]for instance, CHS, FLS, F3H, F3 H, C4H, etc.…”

Section: Discussionmentioning

confidence: 99%

Integrated Analysis of Widely Targeted Metabolomics and Transcriptomics Reveals the Effects of Transcription Factor NOR-like1 on Alkaloids, Phenolic Acids, and Flavonoids in Tomato at Different Ripening Stages

Yang

Zhao

et al. 2022

Metabolites

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Tomato is abundant in alkaloids, phenolic acids, and flavonoids; however, the effect of transcription factor NOR-like1 on these metabolites in tomato is unclear. We used a combination of widely targeted metabolomics and transcriptomics to analyze wild-type tomatoes and CR-NOR-like1 tomatoes. A total of 83 alkaloids, 85 phenolic acids, and 96 flavonoids were detected with significant changes. Combined with a KEGG enrichment analysis, we revealed 16 differentially expressed genes (DEGs) in alkaloid-related arginine and proline metabolism, 60 DEGs were identified in the phenolic acid-related phenylpropane biosynthesis, and 30 DEGs were identified in the flavonoid-related biosynthesis pathway. In addition, some highly correlated differential-expression genes with differential metabolites were further identified by correlation analysis. The present research provides a preliminary view of the effects of NOR-like1 transcription factor on alkaloid, phenolic acid, and flavonoid accumulation in tomatoes at different ripening stages based on widely targeted metabolomics and transcriptomics in plants, laying the foundation for extending fruit longevity and shelf life as well as cultivating stress-resistant plants.

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Section: Discussionmentioning

confidence: 99%

Integrated Analysis of Widely Targeted Metabolomics and Transcriptomics Reveals the Effects of Transcription Factor NOR-like1 on Alkaloids, Phenolic Acids, and Flavonoids in Tomato at Different Ripening Stages

Yang

Zhao

et al. 2022

Metabolites

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“…Given the involvement of oxidative/nitrosative stress in photoreceptor cell death under diabetic conditions, we set out to evaluate antioxidants as preventive agents of the nitrosative effects on the retina under high glucose conditions. To this end, we treated retinal explant cultures with boldine, which is known for its antioxidant properties, apart from its reported role as a hemichannel blocker [38,39]. To establish if boldine could counteract the effects caused by nitrosative stress, we treated retinal explants with SIN-1 together with boldine (Figure 3A).…”

Section: Retinal Cell Death Rate Is Increased By Exposure To High Glu...mentioning

confidence: 99%

Evaluation of Photobiomodulation and Boldine as Alternative Treatment Options in Two Diabetic Retinopathy Models

García

Cadiz

Herrera

et al. 2023

IJMS

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Diabetic retinopathy causes progressive and irreversible damage to the retina through activation of inflammatory processes, overproduction of oxidative species, and glial reactivity, leading to changes in neuronal function and finally ischemia, edema, and hemorrhages. Current treatments are invasive and mostly applied at advanced stages, stressing the need for alternatives. To this end, we tested two unconventional and potentially complementary non-invasive treatment options: Photobiomodulation, the stimulation with near-infrared light, has shown promising results in ameliorating retinal pathologies and insults in several studies but remains controversial. Boldine, on the other hand, is a potent natural antioxidant and potentially useful to prevent free radical-induced oxidative stress. To establish a baseline, we first evaluated the effects of diabetic conditions on the retina with immunofluorescence, histological, and ultrastructural analysis in two diabetes model systems, obese LepRdb/db mice and organotypic retinal explants, and then tested the potential benefits of photobiomodulation and boldine treatment in vitro on retinal explants subjected to high glucose concentrations, mimicking diabetic conditions. Our results suggest that the principal subcellular structures affected by these conditions were mitochondria in the inner segment of photoreceptors, which displayed morphological changes in both model systems. In retinal explants, lactate metabolism, assayed as an indicator of mitochondrial function, was altered, and decreased photoreceptor viability was observed, presumably as a consequence of increased oxidative-nitrosative stress. The latter was reduced by boldine treatment in vitro, while photobiomodulation improved mitochondrial metabolism but was insufficient to prevent retinal structural damage caused by high glucose. These results warrant further research into alternative and complementary treatment options for diabetic retinopathy.

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“…), flavonoids (isorramnetin 3-O-glucoside-7-O-rhamnoside, ramnetin 3-O-arabinosidse 3’-O-rhamnopyranoside, etc. ), phenolic compounds, and essential oils [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Peumus boldus Used in the Synthesis of ZnO Semiconductor Nanoparticles and Their Evaluation in Organic Contaminants

Maro,

Gálvez,

Olivas

et al. 2023

Materials

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The high demand for nanomaterials in the field of industry and science has forced researchers to develop new synthesis methods that are more efficient, economical, and environmentally friendly. At present, the application of green synthesis has taken a great advantage over conventional synthesis methods because it helps with the control of the characteristics and properties of the resulting nanomaterials. In this research, ZnO nanoparticles (NPs) were synthesized by biosynthesis using dried boldo (Peumus boldus) leaves. The resulting biosynthesized NPs had a high purity, quasi-spherical shape with average sizes ranging from 15 to 30 nm and a band gap of ~2.8–3.1 eV. These NPs were used in the photocatalytic activity of three organic dyes. The results showed degradation of 100% methylene blue (MB) in 180 min, 92% methyl orange (MO) in 180 min, and 100% Rhodamine B (RhB) in 30 min of exposure. These results show that the Peumus boldus leaf extract is effective in the biosynthesis of ZnO NPs with good photocatalytic properties.

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Biochemical characterization of Peumus boldus fruits: Insights of its antioxidant properties through a theoretical approach

Cited by 4 publications

References 38 publications

Integrated Analysis of Widely Targeted Metabolomics and Transcriptomics Reveals the Effects of Transcription Factor NOR-like1 on Alkaloids, Phenolic Acids, and Flavonoids in Tomato at Different Ripening Stages

Integrated Analysis of Widely Targeted Metabolomics and Transcriptomics Reveals the Effects of Transcription Factor NOR-like1 on Alkaloids, Phenolic Acids, and Flavonoids in Tomato at Different Ripening Stages

Evaluation of Photobiomodulation and Boldine as Alternative Treatment Options in Two Diabetic Retinopathy Models

Peumus boldus Used in the Synthesis of ZnO Semiconductor Nanoparticles and Their Evaluation in Organic Contaminants

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