Biochemical characterization of naturally occurring mutations in SARS-CoV-2 RNA-dependent RNA polymerase
Matěj Danda,
Anna Klimešová,
Klára Kušková
et al.
Abstract:Since the emergence of SARS-CoV-2, mutations in all subunits of the RNA-dependent RNA polymerase (RdRp) of the virus have been repeatedly reported. Although RdRp represents a primary target for antiviral drugs, experimental studies exploring the phenotypic effect of these mutations have been limited. This study focuses on the phenotypic effects of substitutions in the three RdRp subunits: nsp7, nsp8, and nsp12, selected based on their occurrence rate and potential impact. We employed nano-differential scanning… Show more
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